Towards the rational design of novel drugs based on solubility, partitioning/distribution, biomimetic permeability and biological activity exemplified by 1,2,4-thiadiazole derivatives

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Towards the rational design of novel drugs based on solubility, partitioning/distribution, biomimetic permeability and biological activity exemplified by 1,2,4-thiadiazole derivatives. / Volkova, T. V.; Terekhova, I. V.; Silyukov, O. I.; Proshin, A. N.; Bauer-Brandl, A.; Perlovich, G. L.

в: MedChemComm, Том 8, № 1, 01.01.2017, стр. 162-175.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{adc0ab63e63047c2970609b796de61aa,

title = "Towards the rational design of novel drugs based on solubility, partitioning/distribution, biomimetic permeability and biological activity exemplified by 1,2,4-thiadiazole derivatives",

abstract = "Novel 1,2,4-thiadiazole derivatives as potent neuroprotectors were synthesized and identified. Their ability to inhibit the glutamate stimulated Ca2+ uptake was investigated. The solubility of thiadiazoles was measured in a buffer solution (pH 7.4) at 298 K. The distribution coefficients in 1-octanol/buffer (pH 7.4) and 1-hexane/buffer (pH 7.4) immiscible phases as model systems imitating the gastrointestinal tract epithelium and the blood-brain barrier were determined. Permeation experiments the new Permeapad{\texttrademark} barrier using Franz diffusion cells were conducted and the apparent permeability coefficients were obtained. The influence of the compound structure on the physicochemical properties determining the bioavailability of drug-like substances was revealed. Solubility-permeability interplay has been assessed to evaluate potential bioavailability of the compounds studied.",

author = "Volkova, {T. V.} and Terekhova, {I. V.} and Silyukov, {O. I.} and Proshin, {A. N.} and A. Bauer-Brandl and Perlovich, {G. L.}",

year = "2017",

month = jan,

day = "1",

doi = "10.1039/c6md00545d",

language = "English",

volume = "8",

pages = "162--175",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "1",

}

RIS

TY - JOUR

T1 - Towards the rational design of novel drugs based on solubility, partitioning/distribution, biomimetic permeability and biological activity exemplified by 1,2,4-thiadiazole derivatives

AU - Volkova, T. V.

AU - Terekhova, I. V.

AU - Silyukov, O. I.

AU - Proshin, A. N.

AU - Bauer-Brandl, A.

AU - Perlovich, G. L.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Novel 1,2,4-thiadiazole derivatives as potent neuroprotectors were synthesized and identified. Their ability to inhibit the glutamate stimulated Ca2+ uptake was investigated. The solubility of thiadiazoles was measured in a buffer solution (pH 7.4) at 298 K. The distribution coefficients in 1-octanol/buffer (pH 7.4) and 1-hexane/buffer (pH 7.4) immiscible phases as model systems imitating the gastrointestinal tract epithelium and the blood-brain barrier were determined. Permeation experiments the new Permeapad™ barrier using Franz diffusion cells were conducted and the apparent permeability coefficients were obtained. The influence of the compound structure on the physicochemical properties determining the bioavailability of drug-like substances was revealed. Solubility-permeability interplay has been assessed to evaluate potential bioavailability of the compounds studied.

AB - Novel 1,2,4-thiadiazole derivatives as potent neuroprotectors were synthesized and identified. Their ability to inhibit the glutamate stimulated Ca2+ uptake was investigated. The solubility of thiadiazoles was measured in a buffer solution (pH 7.4) at 298 K. The distribution coefficients in 1-octanol/buffer (pH 7.4) and 1-hexane/buffer (pH 7.4) immiscible phases as model systems imitating the gastrointestinal tract epithelium and the blood-brain barrier were determined. Permeation experiments the new Permeapad™ barrier using Franz diffusion cells were conducted and the apparent permeability coefficients were obtained. The influence of the compound structure on the physicochemical properties determining the bioavailability of drug-like substances was revealed. Solubility-permeability interplay has been assessed to evaluate potential bioavailability of the compounds studied.

UR - http://www.scopus.com/inward/record.url?scp=85010739476&partnerID=8YFLogxK

U2 - 10.1039/c6md00545d

DO - 10.1039/c6md00545d

M3 - Article

AN - SCOPUS:85010739476

VL - 8

SP - 162

EP - 175

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 1

ER -

ID: 37016693