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Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives. / Abzianidze, Victoria V.; Zakharenkova, Sofya A.; Moiseeva, Natalia I.; Beltyukov, Petr P.; Polukeev, Valeriy A.; Dubrovskii, Yaroslav A.; Kuznetsov, Victor A.; Trishin, Yuri G.; Mejia, Jennifer E.; Holder, Alvin A.

в: Bioorganic and Medicinal Chemistry Letters, Том 29, № 1, 01.01.2019, стр. 59-61.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Abzianidze, VV, Zakharenkova, SA, Moiseeva, NI, Beltyukov, PP, Polukeev, VA, Dubrovskii, YA, Kuznetsov, VA, Trishin, YG, Mejia, JE & Holder, AA 2019, 'Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives', Bioorganic and Medicinal Chemistry Letters, Том. 29, № 1, стр. 59-61. https://doi.org/10.1016/j.bmcl.2018.11.003

APA

Abzianidze, V. V., Zakharenkova, S. A., Moiseeva, N. I., Beltyukov, P. P., Polukeev, V. A., Dubrovskii, Y. A., Kuznetsov, V. A., Trishin, Y. G., Mejia, J. E., & Holder, A. A. (2019). Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives. Bioorganic and Medicinal Chemistry Letters, 29(1), 59-61. https://doi.org/10.1016/j.bmcl.2018.11.003

Vancouver

Abzianidze VV, Zakharenkova SA, Moiseeva NI, Beltyukov PP, Polukeev VA, Dubrovskii YA и пр. Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives. Bioorganic and Medicinal Chemistry Letters. 2019 Янв. 1;29(1):59-61. https://doi.org/10.1016/j.bmcl.2018.11.003

Author

Abzianidze, Victoria V. ; Zakharenkova, Sofya A. ; Moiseeva, Natalia I. ; Beltyukov, Petr P. ; Polukeev, Valeriy A. ; Dubrovskii, Yaroslav A. ; Kuznetsov, Victor A. ; Trishin, Yuri G. ; Mejia, Jennifer E. ; Holder, Alvin A. / Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives. в: Bioorganic and Medicinal Chemistry Letters. 2019 ; Том 29, № 1. стр. 59-61.

BibTeX

@article{5f67dd2b62fa4c49a95a25c3cbc91a26,
title = "Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives",
abstract = "New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor studies were carried out on the U937, HCT-116, PC3, MCF-7, A549, К562, NCI-H929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 (IC50 = 0.59 ± 0.27 µM) was observed to be 11 times more active than PPA (IC50 = 6.5 ± 0.30 µM) towards the NCI-H929 cell line, with a therapeutic index of 18. Compound 6 was determined to be over half and 16 times more active than etoposide towards the NCI-H929 (IC50 = 0.9 ± 0.05 µM) and A549 (IC50 = 100 ± 7.0 µM) cell lines, respectively.",
keywords = "Anti-cancer agents, Etoposide, HCT-116 cell line, HEF cell line, In vitro studies, Mercapto derivative, Natural products, Phaeosphaeride A, Therapeutic index, FLUORINE, NATURAL PHAEOSPHAERIDE",
author = "Abzianidze, {Victoria V.} and Zakharenkova, {Sofya A.} and Moiseeva, {Natalia I.} and Beltyukov, {Petr P.} and Polukeev, {Valeriy A.} and Dubrovskii, {Yaroslav A.} and Kuznetsov, {Victor A.} and Trishin, {Yuri G.} and Mejia, {Jennifer E.} and Holder, {Alvin A.}",
year = "2019",
month = jan,
day = "1",
doi = "10.1016/j.bmcl.2018.11.003",
language = "English",
volume = "29",
pages = "59--61",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives

AU - Abzianidze, Victoria V.

AU - Zakharenkova, Sofya A.

AU - Moiseeva, Natalia I.

AU - Beltyukov, Petr P.

AU - Polukeev, Valeriy A.

AU - Dubrovskii, Yaroslav A.

AU - Kuznetsov, Victor A.

AU - Trishin, Yuri G.

AU - Mejia, Jennifer E.

AU - Holder, Alvin A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor studies were carried out on the U937, HCT-116, PC3, MCF-7, A549, К562, NCI-H929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 (IC50 = 0.59 ± 0.27 µM) was observed to be 11 times more active than PPA (IC50 = 6.5 ± 0.30 µM) towards the NCI-H929 cell line, with a therapeutic index of 18. Compound 6 was determined to be over half and 16 times more active than etoposide towards the NCI-H929 (IC50 = 0.9 ± 0.05 µM) and A549 (IC50 = 100 ± 7.0 µM) cell lines, respectively.

AB - New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor studies were carried out on the U937, HCT-116, PC3, MCF-7, A549, К562, NCI-H929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 (IC50 = 0.59 ± 0.27 µM) was observed to be 11 times more active than PPA (IC50 = 6.5 ± 0.30 µM) towards the NCI-H929 cell line, with a therapeutic index of 18. Compound 6 was determined to be over half and 16 times more active than etoposide towards the NCI-H929 (IC50 = 0.9 ± 0.05 µM) and A549 (IC50 = 100 ± 7.0 µM) cell lines, respectively.

KW - Anti-cancer agents

KW - Etoposide

KW - HCT-116 cell line

KW - HEF cell line

KW - In vitro studies

KW - Mercapto derivative

KW - Natural products

KW - Phaeosphaeride A

KW - Therapeutic index

KW - FLUORINE

KW - NATURAL PHAEOSPHAERIDE

UR - http://www.scopus.com/inward/record.url?scp=85056508587&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/towards-lead-compounds-anticancer-agents-via-new-phaeosphaeride-derivatives

U2 - 10.1016/j.bmcl.2018.11.003

DO - 10.1016/j.bmcl.2018.11.003

M3 - Article

AN - SCOPUS:85056508587

VL - 29

SP - 59

EP - 61

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 1

ER -

ID: 36363510