Three-component [2+2+1] gold(I)-catalyzed reaction of internal alkynes (alkynyl esters or -ketones), nitriles, and 2-chloropyridine N-oxide led to a wide range of fully substituted 1,3-oxazoles (32 examples; up to 92% isolated yields). Nitrile R ³ CN species, employed in the reaction as both reactants and solvents, comprise conventional nitriles (R ³ =Alk, Ar) and also push-pull systems such as cyanamides (R ³ =NH ₂ and NAlk ₂ ) and the thiocyanate (R ³ =SPr). The advantages of the developed method include mild reaction conditions, high functional-group tolerance, broad range of substituents R ¹ /R ³ along with a possibility of easy modification of COR ² or the amino group when R ¹ =NH ₂ . (Figure presented.).