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Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins. / Terekhova, Irina V.; Chislov, Mikhail V.; Brusnikina, Maria A.; Chibunova, Ekaterina S.; Volkova, Tatyana V.; Zvereva, Irina A.; Proshin, Alexey N.

в: Chemical Physics Letters, Том 671, 2017, стр. 28-36.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Terekhova, IV, Chislov, MV, Brusnikina, MA, Chibunova, ES, Volkova, TV, Zvereva, IA & Proshin, AN 2017, 'Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins', Chemical Physics Letters, Том. 671, стр. 28-36. https://doi.org/10.1016/j.cplett.2017.01.010

APA

Terekhova, I. V., Chislov, M. V., Brusnikina, M. A., Chibunova, E. S., Volkova, T. V., Zvereva, I. A., & Proshin, A. N. (2017). Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins. Chemical Physics Letters, 671, 28-36. https://doi.org/10.1016/j.cplett.2017.01.010

Vancouver

Terekhova IV, Chislov MV, Brusnikina MA, Chibunova ES, Volkova TV, Zvereva IA и пр. Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins. Chemical Physics Letters. 2017;671:28-36. https://doi.org/10.1016/j.cplett.2017.01.010

Author

Terekhova, Irina V. ; Chislov, Mikhail V. ; Brusnikina, Maria A. ; Chibunova, Ekaterina S. ; Volkova, Tatyana V. ; Zvereva, Irina A. ; Proshin, Alexey N. / Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins. в: Chemical Physics Letters. 2017 ; Том 671. стр. 28-36.

BibTeX

@article{94802704a4874b4d8ce80d7facf25cad,
title = "Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins",
abstract = "Study of complex formation of cyclodextrins with 1,2,4-thiadiazole derivatives intended for Alzheimer's disease treatment was carried out using1H NMR, ITC and phase solubility methods. Structure of cyclodextrins and thiadiazoles affects the binding mode and thermodynamics of complexation. The larger cavity of β- and γ-cyclodextrins is more appropriate for deeper insertion of 1,2,4-thiadiazole derivatives which is accompanied by intensive dehydration and solvent reorganization. Benzene ring of the thiadiazoles is located inside macrocyclic cavity while piperidine ring is placed outside the cavity and can form H-bonds with cyclodextrin exterior. Complexation with cyclodextrins induces the enhancement of aqueous solubility of 1,2,4-thiadiazole derivatives.",
keywords = "1,2,4-Thiadiazole derivatives, Alzheimer's disease, Complex formation, Cyclodextrins, Solubility, Spectroscopy, Thermodynamics",
author = "Terekhova, {Irina V.} and Chislov, {Mikhail V.} and Brusnikina, {Maria A.} and Chibunova, {Ekaterina S.} and Volkova, {Tatyana V.} and Zvereva, {Irina A.} and Proshin, {Alexey N.}",
note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2017",
doi = "10.1016/j.cplett.2017.01.010",
language = "English",
volume = "671",
pages = "28--36",
journal = "Chemical Physics Letters",
issn = "0009-2614",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins

AU - Terekhova, Irina V.

AU - Chislov, Mikhail V.

AU - Brusnikina, Maria A.

AU - Chibunova, Ekaterina S.

AU - Volkova, Tatyana V.

AU - Zvereva, Irina A.

AU - Proshin, Alexey N.

N1 - Publisher Copyright: © 2017 Elsevier B.V. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017

Y1 - 2017

N2 - Study of complex formation of cyclodextrins with 1,2,4-thiadiazole derivatives intended for Alzheimer's disease treatment was carried out using1H NMR, ITC and phase solubility methods. Structure of cyclodextrins and thiadiazoles affects the binding mode and thermodynamics of complexation. The larger cavity of β- and γ-cyclodextrins is more appropriate for deeper insertion of 1,2,4-thiadiazole derivatives which is accompanied by intensive dehydration and solvent reorganization. Benzene ring of the thiadiazoles is located inside macrocyclic cavity while piperidine ring is placed outside the cavity and can form H-bonds with cyclodextrin exterior. Complexation with cyclodextrins induces the enhancement of aqueous solubility of 1,2,4-thiadiazole derivatives.

AB - Study of complex formation of cyclodextrins with 1,2,4-thiadiazole derivatives intended for Alzheimer's disease treatment was carried out using1H NMR, ITC and phase solubility methods. Structure of cyclodextrins and thiadiazoles affects the binding mode and thermodynamics of complexation. The larger cavity of β- and γ-cyclodextrins is more appropriate for deeper insertion of 1,2,4-thiadiazole derivatives which is accompanied by intensive dehydration and solvent reorganization. Benzene ring of the thiadiazoles is located inside macrocyclic cavity while piperidine ring is placed outside the cavity and can form H-bonds with cyclodextrin exterior. Complexation with cyclodextrins induces the enhancement of aqueous solubility of 1,2,4-thiadiazole derivatives.

KW - 1,2,4-Thiadiazole derivatives

KW - Alzheimer's disease

KW - Complex formation

KW - Cyclodextrins

KW - Solubility

KW - Spectroscopy

KW - Thermodynamics

UR - http://www.scopus.com/inward/record.url?scp=85009188372&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2017.01.010

DO - 10.1016/j.cplett.2017.01.010

M3 - Article

AN - SCOPUS:85009188372

VL - 671

SP - 28

EP - 36

JO - Chemical Physics Letters

JF - Chemical Physics Letters

SN - 0009-2614

ER -

ID: 70818053