The paper is devoted to thermodynamic investigation of polyhydroxylated fullerene C₇₀(OH)₁₂. The measurement of fullerenol's isobaric heat capacity in the temperature range T = 9.2 K–304.5 K was performed, as well as the standard thermodynamic functions: S_m°, [H_m°(T) − H_m°(0)] and [Ф_m°(T) − Ф_m°(0)] were calculated. Additionally, the complex thermal analysis was conducted for investigation of thermal properties of C₇₀(OH)₁₂. The quantum chemistry approach was used in order to calculate the electronic structure, thermodynamic properties, and NMR spectra for C₇₀(OH)₁₂ isomers.