DOI

Poly(N-isopropyl acrylamide) grafted heparin and chondroitin sulfate were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The copolymers were characterized by NMR, IR, SEC, DLS, SLS and NTA methods. High grafting densities were reached for both glycosaminoglycans. The temperature, pH and polymer concentration affected the low critical solution temperatures values. The increased pNIPAAm chain length, grafting density and concentration led to the sharp phase transition at 35 °C. Spherical nanogels were formed around this temperature. Terminal dodecyl trithiocarbonate groups of the copolymers were reduced to thiols that allowed formation of sensitive nanogels with sharp phase transitions induced by pNIPAAm chains. The copolymers showed no toxicity to the ocular cells and they provided the prolonged release of dexamethasone phosphate at 37 °C. These copolymers are interesting alternatives for ocular drug delivery.
Язык оригиналаанглийский
Номер статьи116764
Число страниц13
ЖурналCarbohydrate Polymers
Том248
Дата раннего онлайн-доступа13 июл 2020
DOI
СостояниеОпубликовано - 15 ноя 2020

    Области исследований

  • хондроитин сульфат, гепарин, поли(N-изопропил акриламид), обратимая передача цепи (RAFT)), термочувствительные полимеры, pH-чувствительные полимеры, высвобождение лекарств

    Предметные области Scopus

  • Фармакология, токсикология и фармацевтика (все)
  • Органическая химия
  • Химия материалов
  • Пластик и полимеры

ID: 61414269