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There and Back Again : Hox clusters use both dna strands. / Novikova, Elena L.; Kulakova, Milana A.

в: Journal of Developmental Biology, Том 9, № 3, 28, 09.2021.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Novikova, EL & Kulakova, MA 2021, 'There and Back Again: Hox clusters use both dna strands', Journal of Developmental Biology, Том. 9, № 3, 28. https://doi.org/10.3390/jdb9030028

APA

Novikova, E. L., & Kulakova, M. A. (2021). There and Back Again: Hox clusters use both dna strands. Journal of Developmental Biology, 9(3), [28]. https://doi.org/10.3390/jdb9030028

Vancouver

Novikova EL, Kulakova MA. There and Back Again: Hox clusters use both dna strands. Journal of Developmental Biology. 2021 Сент.;9(3). 28. https://doi.org/10.3390/jdb9030028

Author

Novikova, Elena L. ; Kulakova, Milana A. / There and Back Again : Hox clusters use both dna strands. в: Journal of Developmental Biology. 2021 ; Том 9, № 3.

BibTeX

@article{be19a72479614810bcbca44e9c00cffe,
title = "There and Back Again: Hox clusters use both dna strands",
abstract = "Bilaterian animals operate the clusters of Hox genes through a rich repertoire of diverse mechanisms. In this review, we will summarize and analyze the accumulated data concerning long non-coding RNAs (lncRNAs) that are transcribed from sense (coding) DNA strands of Hox clusters. It was shown that antisense regulatory RNAs control the work of Hox genes in cis and trans, participate in the establishment and maintenance of the epigenetic code of Hox loci, and can even serve as a source of regulatory peptides that switch cellular energetic metabolism. Moreover, these molecules can be considered as a force that consolidates the cluster into a single whole. We will discuss the examples of antisense transcription of Hox genes in well-studied systems (cell cultures, morphogenesis of vertebrates) and bear upon some interesting examples of antisense Hox RNAs in non-model Protostomia.",
keywords = "Antisense ncRNAs, Antisense transcription, Hox cluster evolution, Hox genes, LinkRNAs, LncRNAs, Long noncoding RNAs, NATs, lncRNAs, MOLECULAR-MECHANISM, HOXD-AS1 REGULATES PROLIFERATION, STEM-CELLS, linkRNAs, ANTISENSE TRANSCRIPTION, LNCRNA HOTAIR, FEEDBACK LOOP, antisense transcription, long noncoding RNAs, LONG NONCODING RNA, HOMEOTIC TRANSFORMATION, CANCER PROGRESSION, antisense ncRNAs, CHROMATIN STATE",
author = "Novikova, {Elena L.} and Kulakova, {Milana A.}",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = sep,
doi = "10.3390/jdb9030028",
language = "English",
volume = "9",
journal = "Journal of Developmental Biology",
issn = "2221-3759",
publisher = "MDPI AG",
number = "3",

}

RIS

TY - JOUR

T1 - There and Back Again

T2 - Hox clusters use both dna strands

AU - Novikova, Elena L.

AU - Kulakova, Milana A.

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/9

Y1 - 2021/9

N2 - Bilaterian animals operate the clusters of Hox genes through a rich repertoire of diverse mechanisms. In this review, we will summarize and analyze the accumulated data concerning long non-coding RNAs (lncRNAs) that are transcribed from sense (coding) DNA strands of Hox clusters. It was shown that antisense regulatory RNAs control the work of Hox genes in cis and trans, participate in the establishment and maintenance of the epigenetic code of Hox loci, and can even serve as a source of regulatory peptides that switch cellular energetic metabolism. Moreover, these molecules can be considered as a force that consolidates the cluster into a single whole. We will discuss the examples of antisense transcription of Hox genes in well-studied systems (cell cultures, morphogenesis of vertebrates) and bear upon some interesting examples of antisense Hox RNAs in non-model Protostomia.

AB - Bilaterian animals operate the clusters of Hox genes through a rich repertoire of diverse mechanisms. In this review, we will summarize and analyze the accumulated data concerning long non-coding RNAs (lncRNAs) that are transcribed from sense (coding) DNA strands of Hox clusters. It was shown that antisense regulatory RNAs control the work of Hox genes in cis and trans, participate in the establishment and maintenance of the epigenetic code of Hox loci, and can even serve as a source of regulatory peptides that switch cellular energetic metabolism. Moreover, these molecules can be considered as a force that consolidates the cluster into a single whole. We will discuss the examples of antisense transcription of Hox genes in well-studied systems (cell cultures, morphogenesis of vertebrates) and bear upon some interesting examples of antisense Hox RNAs in non-model Protostomia.

KW - Antisense ncRNAs

KW - Antisense transcription

KW - Hox cluster evolution

KW - Hox genes

KW - LinkRNAs

KW - LncRNAs

KW - Long noncoding RNAs

KW - NATs

KW - lncRNAs

KW - MOLECULAR-MECHANISM

KW - HOXD-AS1 REGULATES PROLIFERATION

KW - STEM-CELLS

KW - linkRNAs

KW - ANTISENSE TRANSCRIPTION

KW - LNCRNA HOTAIR

KW - FEEDBACK LOOP

KW - antisense transcription

KW - long noncoding RNAs

KW - LONG NONCODING RNA

KW - HOMEOTIC TRANSFORMATION

KW - CANCER PROGRESSION

KW - antisense ncRNAs

KW - CHROMATIN STATE

UR - http://www.scopus.com/inward/record.url?scp=85111399753&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/fe189866-3bbb-3ca7-b065-012c82ac6690/

U2 - 10.3390/jdb9030028

DO - 10.3390/jdb9030028

M3 - Review article

C2 - 34287306

AN - SCOPUS:85111399753

VL - 9

JO - Journal of Developmental Biology

JF - Journal of Developmental Biology

SN - 2221-3759

IS - 3

M1 - 28

ER -

ID: 84463143