TY - JOUR

T1 - The universal soldier: Enzymatic and non‐enzymatic antioxidant functions of serum albumin

AU - Belinskaia, Daria A.

AU - Voronina, Polina A.

AU - Shmurak, Vladimir I.

AU - Vovk, Mikhail A.

AU - Batalova, Anastasia A.

AU - Jenkins, Richard O.

AU - Goncharov, Nikolay V.

N1 - Funding Information: Funding: These studies were supported by the State assignment AAAA‐A18‐118012290142‐9 (chapters 1 and 3), and by the Russian Foundation for Basic Research, grants 18‐015‐00304 (Daria A. Belinskaia and Polina A. Voronina, chapters 2 and 5, including computational and biochemical experiments with human and rat serum albumin) and 19‐34‐90026 (Anastasia A. Batalova and Nikolay V. Goncharov, chapter 4, including computational, biochemical and NMR experiments with bovine serum albumin). Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/10/9

Y1 - 2020/10/9

N2 - As a carrier of many biologically active compounds, blood is exposed to oxidants to a greater extent than the intracellular environment. Serum albumin plays a key role in antioxidant defence under both normal and oxidative stress conditions. This review evaluates data published in the literature and from our own research on the mechanisms of the enzymatic and non‐enzymatic activities of albumin that determine its participation in redox modulation of plasma and intercellular fluid. For the first time, the results of numerous clinical, biochemical, spectroscopic and computational experiments devoted to the study of allosteric modulation of the functional properties of the protein associated with its participation in antioxidant defence are analysed. It has been concluded that it is fundamentally possible to regulate the antioxidant properties of albumin with various ligands, and the binding and/or enzymatic features of the protein by changing its redox status. The perspectives for using the antioxidant properties of albumin in practice are discussed.

AB - As a carrier of many biologically active compounds, blood is exposed to oxidants to a greater extent than the intracellular environment. Serum albumin plays a key role in antioxidant defence under both normal and oxidative stress conditions. This review evaluates data published in the literature and from our own research on the mechanisms of the enzymatic and non‐enzymatic activities of albumin that determine its participation in redox modulation of plasma and intercellular fluid. For the first time, the results of numerous clinical, biochemical, spectroscopic and computational experiments devoted to the study of allosteric modulation of the functional properties of the protein associated with its participation in antioxidant defence are analysed. It has been concluded that it is fundamentally possible to regulate the antioxidant properties of albumin with various ligands, and the binding and/or enzymatic features of the protein by changing its redox status. The perspectives for using the antioxidant properties of albumin in practice are discussed.

KW - Albumin

KW - Allosteric modulation

KW - Antioxidant enzymes

KW - Non‐enzymatic antioxidant molecules

KW - OXIDATIVE STRESS

KW - GLUTATHIONE-PEROXIDASE PHGPX

KW - DRUG-BINDING

KW - REDOX STATE

KW - PARAOXONASE 1

KW - antioxidant enzymes

KW - non-enzymatic antioxidant molecules

KW - FREE-RADICALS

KW - REACTIVE OXYGEN

KW - CONFORMATIONAL-CHANGES

KW - albumin

KW - NITRIC-OXIDE

KW - ETHACRYNIC-ACID

KW - allosteric modulation

UR - http://www.scopus.com/inward/record.url?scp=85092413617&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/82bc61b4-9501-3b80-906d-60cc430c3ec2/

U2 - 10.3390/antiox9100966

DO - 10.3390/antiox9100966

M3 - Review article

AN - SCOPUS:85092413617

VL - 9

SP - 1

EP - 29

JO - Antioxidants

JF - Antioxidants

SN - 2076-3921

IS - 10

M1 - 966

ER -