TY - GEN

T1 - The temporal correlation transfer simulation in a tissue model with anisotropic scattering patterns for the blood flow analyses

AU - Kuzmin, V. L.

AU - Valkov, A. Yu

AU - Zubkov, L. A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The diffuse correlation spectroscopy (DCS) and diffuse near infrared spectroscopy (DNIRS) are the contemporary non-invasive optical methods which have turned out now to be ones of the most required optical tools for assessing tissue health, in regards to mammography, brain, and deep tissue injury. Earlier we reported on an observation, within the DCS technics, of development of pressure injuries measuring dermal and subcutaneous red blood cell motion; the data obtained has produced remarkably a characteristic decay time of the light intensity temporal correlation function being five times larger for patients of the group with developing open pressure injuries as compared with the group exhibiting healthier stage. The quantitative determination of the characteristic time required a definite picture of scatterer motion. For quantitative study the crucial problem to solve is a proper account for the scattering anisotropy. We perform comparative simulations of the diffuse photon density wave (DPDW) signals and the temporal intensity correlation functions either with the Henyey-Greenstein (HG) or Rayleigh-Gans (RG) phase functions, which we consider is more appropriate as the hard sphere suspension model for imitating a tissue. We find that for a half space geometry the results obtained for these two scattering patterns turn to be quite close; however for finite size tissue geometries results of simulations of the source-detector plot for backscattered intensity differ noticeably at small distances; simulating the temporal correlation function with these two phase functions we find the blood flow to be different for different scattering patterns in case of spatial restrictions. The DPDW methodology is widely used in a number of biomedical applications. Here we present results of Monte Carlo simulations that employ an effective numerical procedure, based upon a description of radiative transfer in terms of the Bethe-Salpeter equation, and compare them with measurements from Intralipid aqueous solutions. We find the Monte Carlo simulations and measurements to be in a very good agreement for a wide range of source-detector separations.

AB - The diffuse correlation spectroscopy (DCS) and diffuse near infrared spectroscopy (DNIRS) are the contemporary non-invasive optical methods which have turned out now to be ones of the most required optical tools for assessing tissue health, in regards to mammography, brain, and deep tissue injury. Earlier we reported on an observation, within the DCS technics, of development of pressure injuries measuring dermal and subcutaneous red blood cell motion; the data obtained has produced remarkably a characteristic decay time of the light intensity temporal correlation function being five times larger for patients of the group with developing open pressure injuries as compared with the group exhibiting healthier stage. The quantitative determination of the characteristic time required a definite picture of scatterer motion. For quantitative study the crucial problem to solve is a proper account for the scattering anisotropy. We perform comparative simulations of the diffuse photon density wave (DPDW) signals and the temporal intensity correlation functions either with the Henyey-Greenstein (HG) or Rayleigh-Gans (RG) phase functions, which we consider is more appropriate as the hard sphere suspension model for imitating a tissue. We find that for a half space geometry the results obtained for these two scattering patterns turn to be quite close; however for finite size tissue geometries results of simulations of the source-detector plot for backscattered intensity differ noticeably at small distances; simulating the temporal correlation function with these two phase functions we find the blood flow to be different for different scattering patterns in case of spatial restrictions. The DPDW methodology is widely used in a number of biomedical applications. Here we present results of Monte Carlo simulations that employ an effective numerical procedure, based upon a description of radiative transfer in terms of the Bethe-Salpeter equation, and compare them with measurements from Intralipid aqueous solutions. We find the Monte Carlo simulations and measurements to be in a very good agreement for a wide range of source-detector separations.

KW - Bethe-Salpeter equation

KW - diffuse correlation spectroscopy

KW - Diffuse photon density wave

KW - intensity temporal correlation function

KW - Monte-Carlo modeling

KW - radiative transfer

KW - scattering patterns

KW - OPTICAL-PROPERTIES

KW - NONINVASIVE DETERMINATION

KW - MULTIPLE-SCATTERING

UR - http://www.scopus.com/inward/record.url?scp=85049222544&partnerID=8YFLogxK

UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10685/2314541/The-temporal-correlation-transfer-simulation-in-a-tissue-model-with/10.1117/12.2314541.full

UR - http://www.mendeley.com/research/temporal-correlation-transfer-simulation-tissue-model-anisotropic-scattering-patterns-blood-flow-ana

U2 - 10.1117/12.2314541

DO - 10.1117/12.2314541

M3 - Conference contribution

AN - SCOPUS:85049222544

SN - 9781510618961

VL - 10685

T3 - Proceedings of SPIE

BT - Biophotonics: Photonic Solutions for Better Health Care VI

A2 - Popp, Jurgen

A2 - Tuchin, Valery V.

A2 - Pavone, Francesco Saverio

PB - SPIE

T2 - Biophotonics: Photonic Solutions for Better Health Care VI 2018

Y2 - 23 April 2018 through 26 April 2018

ER -