TY - JOUR

T1 - The template principle: Paradigm of modern genetics

AU - Inge-Vechtomov, S.G.

PY - 2013

Y1 - 2013

N2 - The idea of continuity in living systems, which was initially developed in mid-19th century, reached its peak in 1928 thanks to N. K. Kol'tsov, who proposed the template principle in chromosome reproduction. The determination of genetic functions of nucleic acids and the advent of molecular genetics led to F. Crick's statement of the central dogma of molecular biology in 1958. This dogma became a contemporary version of the template principle (templates of the first order). The discovery of "protein inheritance" underlay the notion of steric or conformational templates (second order) for reproducing conformation in a number of proteins. The template principle supplemented by this notion claims to be the main paradigm of modern genetics. © 2013 Pleiades Publishing, Ltd.

AB - The idea of continuity in living systems, which was initially developed in mid-19th century, reached its peak in 1928 thanks to N. K. Kol'tsov, who proposed the template principle in chromosome reproduction. The determination of genetic functions of nucleic acids and the advent of molecular genetics led to F. Crick's statement of the central dogma of molecular biology in 1958. This dogma became a contemporary version of the template principle (templates of the first order). The discovery of "protein inheritance" underlay the notion of steric or conformational templates (second order) for reproducing conformation in a number of proteins. The template principle supplemented by this notion claims to be the main paradigm of modern genetics. © 2013 Pleiades Publishing, Ltd.

U2 - 10.1134/S1022795413010055

DO - 10.1134/S1022795413010055

M3 - Article

SP - 4

EP - 9

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 1

ER -