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  • Russ JGC_revised

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The synthesis of 3-chloro-6-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)pyridazine and its dideuterated analogue was performed using a novel two-step sequence. On the first step, a double chlorination of 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-hydrazineyl-1,2,4,5-tetrazine with trichlorocyanuric acid was performed to synthesize 3-chloro-6-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine for the first time. The latter reacted with calcium carbide-derived acetylene and D2-acetylene at heating in a two-chamber reactor (COware) producing 3-chloro-6-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)pyridazine or 3-chloro-6-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4,5-dideuteropyridazine respectively in quantitative yields.
Язык оригиналаанглийский
ЖурналRussian Journal of General Chemistry
СостояниеПринято в печать - 21 окт 2024

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  • 1,2,4,5-tetrazine, pyridazine, chlorination, acetylene, Diels-Alder cycloaddition

ID: 126740875