TY - JOUR

T1 - The synapsin cycle

T2 - A view from the synaptic endocytic zone

AU - Evergren, Emma

AU - Benfenati, F.

AU - Shupliakov, O.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Although the synapsin phosphoproteins were discovered more than 30 years ago and are known to play important roles in neurotransmitter release and synaptogenesis, a complete picture of their functions within the nerve terminal is lacking. It has been shown that these proteins play an important role in the clustering of synaptic vesicles (SVs) at active zones and function as modulators of synaptic strength by acting at both pre- and postdocking levels. Recent studies have demonstrated that synapsins migrate to the endocytic zone of central synapses during neurotransmitter release, which suggests that there are additional functions for these proteins in SV recycling.

AB - Although the synapsin phosphoproteins were discovered more than 30 years ago and are known to play important roles in neurotransmitter release and synaptogenesis, a complete picture of their functions within the nerve terminal is lacking. It has been shown that these proteins play an important role in the clustering of synaptic vesicles (SVs) at active zones and function as modulators of synaptic strength by acting at both pre- and postdocking levels. Recent studies have demonstrated that synapsins migrate to the endocytic zone of central synapses during neurotransmitter release, which suggests that there are additional functions for these proteins in SV recycling.

KW - Actin

KW - Periactive zone

KW - SV cycle

KW - Synapse

UR - http://www.scopus.com/inward/record.url?scp=34547832581&partnerID=8YFLogxK

U2 - 10.1002/jnr.21176

DO - 10.1002/jnr.21176

M3 - Article

C2 - 17455288

AN - SCOPUS:34547832581

VL - 85

SP - 2648

EP - 2656

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 12

ER -