TY - CONF

T1 - THE STUDY OF ENVIRONMENTAL EXPOSURES AS A PART OF THE ASIA SYNDROME IN THE DEVELOPMENT OF SARCOIDOSIS

AU - Зинченко, Юлия Сергеевна

AU - Старшинова, Анна Андреевна

AU - Бурдаков, Владимир Станиславович

AU - Яблонский, Петр Казимирович

AU - Денисова, Нина

AU - Зайцев, Иван Сергеевич

AU - Степаненко, Татьяна Александровна

PY - 2018

Y1 - 2018

N2 - Introduction The prevalence of sarcoidosis is increasing, but it’s etiology is still unknown. The role of adjuvants in the development of pathological inflammatory process (Autoimmune Syndrome Induced by Adjuvants - ASIA) was reflected in the work of Y.Shoenfeld (2011). The connection between ASIA and sarcoidosis in genetically predisposed individuals is an actual topic (Bindoli S., 2016). The aim of the study is to identify exogenous factors in the development of sarcoidosis. Material and Methods A retrospective-prospective study within the framework of the Megagrant under the leadership of Y.Shoenfeld is conducted at the Institute of Phthisiopulmonology and St. Petersburg State University. We included patients with lung sarcoidosis (n =49) diagnosed from 2014 to 2016. In 36 (73,5%) sarcoidosis I-II stages was detected, 7(14,3%) patients had Lofgren's syndrome and 6(12,2%) had generalized sarcoidosis. All patients underwent a standard examination complex and an anamnesis data collection using ASIA Research Questionnaire. Differences were significant at p <0.05. Results The most significant risk factors are presented in Table 1. Table 1. Risk factors in the study participants p <0.05 - when comparing risk factors As shown in Table 1, the most significant factors were stress, foreign material and occupational hazards. Smoking, allergies and vaccination were often noted. Time between exposure to foreign material and symptoms’ onset was 10,8 (±8,7) years. Conclusion The most significant factors in the development of sarcoidosis, according to preliminary data, are stress, foreign material and occupational hazards. Smoking, allergies and vaccination may have a significant effect, which requires further research.

AB - Introduction The prevalence of sarcoidosis is increasing, but it’s etiology is still unknown. The role of adjuvants in the development of pathological inflammatory process (Autoimmune Syndrome Induced by Adjuvants - ASIA) was reflected in the work of Y.Shoenfeld (2011). The connection between ASIA and sarcoidosis in genetically predisposed individuals is an actual topic (Bindoli S., 2016). The aim of the study is to identify exogenous factors in the development of sarcoidosis. Material and Methods A retrospective-prospective study within the framework of the Megagrant under the leadership of Y.Shoenfeld is conducted at the Institute of Phthisiopulmonology and St. Petersburg State University. We included patients with lung sarcoidosis (n =49) diagnosed from 2014 to 2016. In 36 (73,5%) sarcoidosis I-II stages was detected, 7(14,3%) patients had Lofgren's syndrome and 6(12,2%) had generalized sarcoidosis. All patients underwent a standard examination complex and an anamnesis data collection using ASIA Research Questionnaire. Differences were significant at p <0.05. Results The most significant risk factors are presented in Table 1. Table 1. Risk factors in the study participants p <0.05 - when comparing risk factors As shown in Table 1, the most significant factors were stress, foreign material and occupational hazards. Smoking, allergies and vaccination were often noted. Time between exposure to foreign material and symptoms’ onset was 10,8 (±8,7) years. Conclusion The most significant factors in the development of sarcoidosis, according to preliminary data, are stress, foreign material and occupational hazards. Smoking, allergies and vaccination may have a significant effect, which requires further research.

KW - THE ASIA SYNDROME

KW - AUTOANTIBODY

KW - SARCOIDOSIS

KW - ENVIRONMENTAL EXPOSURES

M3 - Paper

Y2 - 16 May 2018 through 20 May 2018

ER -