Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The spatial-frequency characteristics of the visual system in schizophrenia. / Shoshina, I. I.; Shelepin, Y. E.; Vershinina, E. A.; Novikova, K. O.
в: Human Physiology, Том 41, № 3, 18.05.2015, стр. 251-260.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The spatial-frequency characteristics of the visual system in schizophrenia
AU - Shoshina, I. I.
AU - Shelepin, Y. E.
AU - Vershinina, E. A.
AU - Novikova, K. O.
N1 - Publisher Copyright: © 2015, Pleiades Publishing, Inc.
PY - 2015/5/18
Y1 - 2015/5/18
N2 - The spatial-frequency characteristics of the visual system were studied in mentally healthy persons and in patients with schizophrenia using a test of contrast sensivity in a comparison of the contrast of two gratings with sinusoidal distribution of brightness and with the low, medium, or high spatial frequencies, which are perceived by neurons of the magnocellular and parvocellular channels with different sensitivities. In the first-episode schizophrenic patients who had received no antipsychotic drugs for a long time, an enhancement of contrast sensitivity as compared to mentally healthy subjects was observed when the patients were presented Gabor gratings with low spatial frequencies to which the magnocellular channel neurons are most sensitive. On the contrary, in the case of the contrast comparison of the gratings with the medium and high spatial frequencies, the contrast sensitivity was reduced in the first-episode schizophrenic patients irrespective of whether they had been non-treated or treated for a long time. In chronic patients with schizophrenia, reduced contrast sensitivity was observed in response to gratings with any frequency range tested. Some additional evidence of the internal noise enhancement in patients with schizophrenia has been also obtained. Our results make it possible to explain clinical data on specific disorders of visual perception at different stages of schizophrenia.
AB - The spatial-frequency characteristics of the visual system were studied in mentally healthy persons and in patients with schizophrenia using a test of contrast sensivity in a comparison of the contrast of two gratings with sinusoidal distribution of brightness and with the low, medium, or high spatial frequencies, which are perceived by neurons of the magnocellular and parvocellular channels with different sensitivities. In the first-episode schizophrenic patients who had received no antipsychotic drugs for a long time, an enhancement of contrast sensitivity as compared to mentally healthy subjects was observed when the patients were presented Gabor gratings with low spatial frequencies to which the magnocellular channel neurons are most sensitive. On the contrary, in the case of the contrast comparison of the gratings with the medium and high spatial frequencies, the contrast sensitivity was reduced in the first-episode schizophrenic patients irrespective of whether they had been non-treated or treated for a long time. In chronic patients with schizophrenia, reduced contrast sensitivity was observed in response to gratings with any frequency range tested. Some additional evidence of the internal noise enhancement in patients with schizophrenia has been also obtained. Our results make it possible to explain clinical data on specific disorders of visual perception at different stages of schizophrenia.
KW - comparison of contrast
KW - first psychotic episode
KW - magnocellular channels
KW - parvocellular channels
KW - schizophrenia
KW - spatial-frequency channels
KW - visual perception
UR - http://www.scopus.com/inward/record.url?scp=84935867217&partnerID=8YFLogxK
U2 - 10.1134/S0362119715030159
DO - 10.1134/S0362119715030159
M3 - Article
AN - SCOPUS:84935867217
VL - 41
SP - 251
EP - 260
JO - Human Physiology
JF - Human Physiology
SN - 0362-1197
IS - 3
ER -
ID: 96971580