TY - JOUR

T1 - The Role of TRP Channels in Sepsis and Colitis

AU - Дворникова, Кристина Алексеевна

AU - Платонова, Ольга Николаевна

AU - Быстрова, Елена Юрьевна

PY - 2024/4/27

Y1 - 2024/4/27

N2 - To date, several members of the transient receptor potential (TRP) channels which provide a wide array of roles have been found in the gastrointestinal tract (GI). The goal of earlier research was to comprehend the intricate signaling cascades that contribute to TRP channel activation as well as how these receptors' activity affects other systems. Moreover, there is a large volume of published studies describing the role of TRP channels in a number of pathological disorders, including inflammatory bowel disease (IBD) and sepsis. Nevertheless, the generalizability of these results is subject to certain limitations. For instance, the study of IBD relies on various animal models and experimental methods, which are unable to precisely imitate the multifactorial chronic disease. The diverse pathophysiological mechanisms and unique susceptibility of animals may account for the inconsistency of the experimental data collected. The main purpose of this study was to conduct a comprehensive review and analysis of existing studies on transient receptor potential (TRP) channels implicating specific models of colitis and sepsis, with particular emphasis on their involvement in pathological disorders such as IBD and sepsis. Furthermore, the text endeavors to evaluate the generalizability of experimental findings, taking into consideration the limitations posed by animal models and experimental methodologies. Finally, we also provide an updated schematic of the most important and possible molecular signaling pathways associated with TRP channels in IBD and sepsis.

AB - To date, several members of the transient receptor potential (TRP) channels which provide a wide array of roles have been found in the gastrointestinal tract (GI). The goal of earlier research was to comprehend the intricate signaling cascades that contribute to TRP channel activation as well as how these receptors' activity affects other systems. Moreover, there is a large volume of published studies describing the role of TRP channels in a number of pathological disorders, including inflammatory bowel disease (IBD) and sepsis. Nevertheless, the generalizability of these results is subject to certain limitations. For instance, the study of IBD relies on various animal models and experimental methods, which are unable to precisely imitate the multifactorial chronic disease. The diverse pathophysiological mechanisms and unique susceptibility of animals may account for the inconsistency of the experimental data collected. The main purpose of this study was to conduct a comprehensive review and analysis of existing studies on transient receptor potential (TRP) channels implicating specific models of colitis and sepsis, with particular emphasis on their involvement in pathological disorders such as IBD and sepsis. Furthermore, the text endeavors to evaluate the generalizability of experimental findings, taking into consideration the limitations posed by animal models and experimental methodologies. Finally, we also provide an updated schematic of the most important and possible molecular signaling pathways associated with TRP channels in IBD and sepsis.

KW - Animals

KW - Colitis/metabolism

KW - Disease Models, Animal

KW - Humans

KW - Inflammatory Bowel Diseases/metabolism

KW - Sepsis/metabolism

KW - Signal Transduction

KW - Transient Receptor Potential Channels/metabolism

KW - colitis

KW - intestine

KW - CLP

KW - LPS

KW - TRP channels

KW - inflammatory bowel disease

KW - endotoxins

KW - inflammation

KW - ulcerative colitis

KW - sepsis

KW - Crohn’s disease

UR - https://www.mendeley.com/catalogue/cad5cb24-3735-38f6-8057-f70a7ed6ac84/

U2 - 10.3390/ijms25094784

DO - 10.3390/ijms25094784

M3 - Review article

C2 - 38731999

VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 9

M1 - 4784

ER -