TY - JOUR

T1 - The role of prenatal melatonin in the regulation of childhood obesity.

AU - Иванов, Дмитрий Олегович

AU - Евсюкова, Инна Ивановна

AU - Mazzoccoli, Gianluigi

AU - Полякова, Виктория Олеговна

AU - Насыров, Руслан Абдуллаевич

PY - 2020

Y1 - 2020

N2 - There is a growing awareness that pregnancy can set the foundations for an array of diverse medical conditions in the offspring, including obesity. A wide assortment of factors, including genetic, epigenetic, lifestyle, and diet can influence foetal outcomes. This article reviews the role of melatonin in the prenatal modulation of offspring obesity. A growing number of studies show that many prenatal risk factors for poor foetal metabolic outcomes, including gestational diabetes and night-shift work, are associated with a decrease in pineal gland-derived melatonin and associated alterations in the circadian rhythm. An important aspect of circadian melatonin's effects is mediated via the circadian gene, BMAL1, including in the regulation of mitochondrial metabolism and the mitochondrial melatoninergic pathway. Alterations in the regulation of mitochondrial metabolic shifts between glycolysis and oxidative phosphorylation in immune and glia cells seem crucial to a host of human medical conditions, including in

AB - There is a growing awareness that pregnancy can set the foundations for an array of diverse medical conditions in the offspring, including obesity. A wide assortment of factors, including genetic, epigenetic, lifestyle, and diet can influence foetal outcomes. This article reviews the role of melatonin in the prenatal modulation of offspring obesity. A growing number of studies show that many prenatal risk factors for poor foetal metabolic outcomes, including gestational diabetes and night-shift work, are associated with a decrease in pineal gland-derived melatonin and associated alterations in the circadian rhythm. An important aspect of circadian melatonin's effects is mediated via the circadian gene, BMAL1, including in the regulation of mitochondrial metabolism and the mitochondrial melatoninergic pathway. Alterations in the regulation of mitochondrial metabolic shifts between glycolysis and oxidative phosphorylation in immune and glia cells seem crucial to a host of human medical conditions, including in

KW - circadian

KW - comorbidity

KW - development

KW - gut

KW - melatonin

KW - metabolism

KW - mitochondria

KW - obesity

KW - postnatal

KW - prenatal

KW - circadian

KW - comorbidity

KW - development

KW - gut

KW - melatonin

KW - metabolism

KW - mitochondria

KW - obesity

KW - postnatal

KW - prenatal

M3 - Article

VL - 9

SP - 72

JO - Biology

JF - Biology

SN - 2079-7737

IS - 4

ER -