Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis. / Lavrushkina, S. V.; Ovsyannikova, N. L.; Yudina, A. S.; Strelkova, O. S.; Zhironkina, O. A.; Perepelina, K. I.; Malashicheva, A. B.; Kireev, I. I.
в: Cell and Tissue Biology, Том 13, № 3, 01.05.2019, стр. 237-241.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis
AU - Lavrushkina, S. V.
AU - Ovsyannikova, N. L.
AU - Yudina, A. S.
AU - Strelkova, O. S.
AU - Zhironkina, O. A.
AU - Perepelina, K. I.
AU - Malashicheva, A. B.
AU - Kireev, I. I.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.
AB - The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.
KW - cell motility
KW - LINC complex
KW - mechanical properties
KW - nuclear lamina
UR - http://www.scopus.com/inward/record.url?scp=85067889960&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/role-mechanical-properties-nucleus-maintaining-tissue-homeostasis
U2 - 10.1134/S1990519X19030064
DO - 10.1134/S1990519X19030064
M3 - Article
AN - SCOPUS:85067889960
VL - 13
SP - 237
EP - 241
JO - Cell and Tissue Biology
JF - Cell and Tissue Biology
SN - 1990-519X
IS - 3
ER -
ID: 45918174