TY - JOUR

T1 - The Role of Extracellular Matrix in Skin Wound Healing

AU - Potekaev, Nikolai N.

AU - Borzykh, Olga B.

AU - Medvedev, German V.

AU - Pushkin, Denis V.

AU - Petrova, Marina M.

AU - Petrov, Artem V.

AU - Dmitrenko, Diana V.

AU - Karpova, Elena I.

AU - Demina, Olga M.

AU - Shnayder, Natalia A.

N1 - Potekaev, N.N.; Borzykh, O.B.; Medvedev, G.V.; Pushkin, D.V.; Petrova, M.M.; Petrov, A.V.; Dmitrenko, D.V.; Karpova, E.I.; Demina, O.M.; Shnayder, N.A. The Role of Extracellular Matrix in Skin Wound Healing. J. Clin. Med. 2021, 10, 5947. https://doi.org/10.3390/jcm10245947

PY - 2021/12/18

Y1 - 2021/12/18

N2 - Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients’ quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

AB - Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients’ quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

KW - заживление ран; внеклеточный матрикс кожи; нарушение регенерации

KW - wound healing

KW - extracellular skin matrix

KW - violation of regeneration

KW - Wound healing

KW - Violation of regeneration

KW - Extracellular skin matrix

UR - https://www.mdpi.com/2077-0383/10/24/5947

UR - http://www.scopus.com/inward/record.url?scp=85121288933&partnerID=8YFLogxK

U2 - 10.3390/jcm10245947

DO - 10.3390/jcm10245947

M3 - Article

VL - 10

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 24

M1 - 5947

ER -