Результаты исследований: Научные публикации в периодических изданиях › письмо/краткое сообщение
The opposite effect of HLA-genotypes in sarcoidosis and tuberculosis (literature review). / Malkova, Anna ; Starshinova, Anna; Zinchenko, Yulia; Bazantsova, Natalia; Mayevskaya, Vera ; Yablonskiy, Piotr; Shoenfeld, Yehuda.
в: ERJ Open Research, Том 6, № 3, 00155-2020, 11.08.2020.Результаты исследований: Научные публикации в периодических изданиях › письмо/краткое сообщение
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TY - JOUR
T1 - The opposite effect of HLA-genotypes in sarcoidosis and tuberculosis (literature review)
AU - Malkova, Anna
AU - Starshinova, Anna
AU - Zinchenko, Yulia
AU - Bazantsova, Natalia
AU - Mayevskaya, Vera
AU - Yablonskiy, Piotr
AU - Shoenfeld, Yehuda
PY - 2020/8/11
Y1 - 2020/8/11
N2 - Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics that make some researchers consider a common pathogenesis for these diseases. Human leukocyte antigen (HLA) genotypes are studied both in sarcoidosis and tuberculosis patients, but to our knowledge, there are no comparative studies of genetic predisposition for sarcoidosis and tuberculosis development.The aim of this review was to analyse the relationship between HLA genotypes and the development of sarcoidosis and tuberculosis. Original and review articles published in various online databases from 1960 to 2019 were studied.The search results showed opposite effects of the HLA genotypes on predisposition to sarcoidosis or tuberculosis. It was revealed that the genotypes predisposing to the development of sarcoidosis (HLA-DRB1*03/07/15) have protective properties against the development of tuberculosis. Moreover, genotypes causing the development of tuberculosis (HLA-DRB1*04) have a protective effect on the development of sarcoidosis.The results of this narrative review of the literature may allude to the existence of genetic predispositions that lead to the development of an antibacterial or autoimmune response to mycobacteria.
AB - Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics that make some researchers consider a common pathogenesis for these diseases. Human leukocyte antigen (HLA) genotypes are studied both in sarcoidosis and tuberculosis patients, but to our knowledge, there are no comparative studies of genetic predisposition for sarcoidosis and tuberculosis development.The aim of this review was to analyse the relationship between HLA genotypes and the development of sarcoidosis and tuberculosis. Original and review articles published in various online databases from 1960 to 2019 were studied.The search results showed opposite effects of the HLA genotypes on predisposition to sarcoidosis or tuberculosis. It was revealed that the genotypes predisposing to the development of sarcoidosis (HLA-DRB1*03/07/15) have protective properties against the development of tuberculosis. Moreover, genotypes causing the development of tuberculosis (HLA-DRB1*04) have a protective effect on the development of sarcoidosis.The results of this narrative review of the literature may allude to the existence of genetic predispositions that lead to the development of an antibacterial or autoimmune response to mycobacteria.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418820/
M3 - Letter
VL - 6
JO - ERJ Open Research
JF - ERJ Open Research
SN - 2312-0541
IS - 3
M1 - 00155-2020
ER -
ID: 50653490