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The interaction of DNA with coordination compounds of platinum and cobalt in solution. / Kas'yanenko, N. A.; Bogdanov, A. A.; Defrenne, S.
в: Biofizika, Том 47, № 3, 2002, стр. 452.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The interaction of DNA with coordination compounds of platinum and cobalt in solution
AU - Kas'yanenko, N. A.
AU - Bogdanov, A. A.
AU - Defrenne, S.
N1 - Copyright: Copyright 2005 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - The interaction of DNA with coordination compounds of divalent platinum and tri valent cobalt was studied. Complexes containing simultaneously different coordination compounds were prepared by various procedures. It was shown that the binding of trans-diaminodichloroplatinum (DDP) to DNA prevents its further complexing with cis-DDP, while in the presence of cis-DDP the possibility for trans-DDP to bind to DNA in solution remains. The study of similar DNA complexes with trans-DDP and cobalt hexamine indicated the competition for the binding sites of these compounds to the DNA molecule.
AB - The interaction of DNA with coordination compounds of divalent platinum and tri valent cobalt was studied. Complexes containing simultaneously different coordination compounds were prepared by various procedures. It was shown that the binding of trans-diaminodichloroplatinum (DDP) to DNA prevents its further complexing with cis-DDP, while in the presence of cis-DDP the possibility for trans-DDP to bind to DNA in solution remains. The study of similar DNA complexes with trans-DDP and cobalt hexamine indicated the competition for the binding sites of these compounds to the DNA molecule.
KW - Coordination compounds of platinum and cobalt
KW - DNA molecule
KW - Interaction
UR - http://www.scopus.com/inward/record.url?scp=0038842397&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0038842397
VL - 47
SP - 452
JO - БИОФИЗИКА
JF - БИОФИЗИКА
SN - 0006-3029
IS - 3
ER -
ID: 73391982