TY - JOUR

T1 - The importance of speciation analysis in neurodegeneration research

AU - Michalke, Bernhard

AU - Willkommen, Desiree

AU - Drobyshev, Evgenii

AU - Solovyev, Nikolay

PY - 2017

Y1 - 2017

N2 - Element speciation offers deeper insight into the molecular mechanisms of disease by determining element species pattern. Thus, having great potential for investigating neurodegeneration in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and mild cognitive impairment, speciation is increasingly considered in epidemiological or clinical neurological studies. This review analyses recent speciation findings in neurodegeneration research, concentrating on measurements in cerebrospinal fluid and brain. Elements considered are aluminum, arsenic, copper, iron, mercury, manganese, selenium and zinc. Also interactions of trace element species are discussed briefly. Typically, hyphenated techniques are used in neurodegeneration speciation studies. The results allow sorting-out less important species from compounds significant for the disease, with subsequent use of molecular biology methods to uncover the exact mechanisms. This review indicates the trend of combining speciation and neuroscience and provides a sketch about data and outcomes. For brain research, we recommend using modern, powerful techniques throughout which provide advanced validity and information in a chemical sense.

AB - Element speciation offers deeper insight into the molecular mechanisms of disease by determining element species pattern. Thus, having great potential for investigating neurodegeneration in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and mild cognitive impairment, speciation is increasingly considered in epidemiological or clinical neurological studies. This review analyses recent speciation findings in neurodegeneration research, concentrating on measurements in cerebrospinal fluid and brain. Elements considered are aluminum, arsenic, copper, iron, mercury, manganese, selenium and zinc. Also interactions of trace element species are discussed briefly. Typically, hyphenated techniques are used in neurodegeneration speciation studies. The results allow sorting-out less important species from compounds significant for the disease, with subsequent use of molecular biology methods to uncover the exact mechanisms. This review indicates the trend of combining speciation and neuroscience and provides a sketch about data and outcomes. For brain research, we recommend using modern, powerful techniques throughout which provide advanced validity and information in a chemical sense.

KW - Brain

KW - Cerebrospinal fluid

KW - High pressure liquid chromatography

KW - Hyphenated techniques

KW - Inductively coupled plasma mass spectrometry

KW - Neurodegeneration

KW - Quality control

KW - Redox stability

KW - Speciation

KW - Trace element

UR - http://www.scopus.com/inward/record.url?scp=85028669730&partnerID=8YFLogxK

U2 - 10.1016/j.trac.2017.08.008

DO - 10.1016/j.trac.2017.08.008

M3 - Article

AN - SCOPUS:85028669730

VL - 104

SP - 160

EP - 170

JO - TrAC - Trends in Analytical Chemistry

JF - TrAC - Trends in Analytical Chemistry

SN - 0165-9936

ER -