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The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. / Sela, D. A.; Chapman, J.; Adeuya, A.; Kim, J. H.; Chen, F.; Whitehead, T. R.; Lapidus, A.; Rokhsar, D. S.; Lebrilla, C. B.; German, J. B.; Price, N. P.; Richardson, P. M.; Mills, D. A.

в: Proceedings of the National Academy of Sciences of the United States of America, Том 105, № 48, 02.12.2008, стр. 18964-18969.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Sela, DA, Chapman, J, Adeuya, A, Kim, JH, Chen, F, Whitehead, TR, Lapidus, A, Rokhsar, DS, Lebrilla, CB, German, JB, Price, NP, Richardson, PM & Mills, DA 2008, 'The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome', Proceedings of the National Academy of Sciences of the United States of America, Том. 105, № 48, стр. 18964-18969. https://doi.org/10.1073/pnas.0809584105

APA

Sela, D. A., Chapman, J., Adeuya, A., Kim, J. H., Chen, F., Whitehead, T. R., Lapidus, A., Rokhsar, D. S., Lebrilla, C. B., German, J. B., Price, N. P., Richardson, P. M., & Mills, D. A. (2008). The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proceedings of the National Academy of Sciences of the United States of America, 105(48), 18964-18969. https://doi.org/10.1073/pnas.0809584105

Vancouver

Sela DA, Chapman J, Adeuya A, Kim JH, Chen F, Whitehead TR и пр. The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proceedings of the National Academy of Sciences of the United States of America. 2008 Дек. 2;105(48):18964-18969. https://doi.org/10.1073/pnas.0809584105

Author

Sela, D. A. ; Chapman, J. ; Adeuya, A. ; Kim, J. H. ; Chen, F. ; Whitehead, T. R. ; Lapidus, A. ; Rokhsar, D. S. ; Lebrilla, C. B. ; German, J. B. ; Price, N. P. ; Richardson, P. M. ; Mills, D. A. / The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. в: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Том 105, № 48. стр. 18964-18969.

BibTeX

@article{46f2a71e6f644a6fb4037ddaafae449b,
title = "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome",
abstract = "Following birth, the breast-fed infant gastrointestinal tract is rapidly colonized by a microbial consortium often dominated by bifidobacteria. Accordingly, the complete genome sequence of Bifidobacterium longum subsp. infantis ATCC15697 reflects a competitive nutrient-utilization strategy targeting milk-borne molecules which lack a nutritive value to the neonate. Several chromosomal loci reflect potential adaptation to the infant host including a 43 kbp cluster encoding catabolic genes, extracellular solute binding proteins and permeases predicted to be active on milk oligosaccharides. An examination of in vivo metabolism has detected the hallmarks of milk oligosaccharide utilization via the central fermentative pathway using metabolomic and proteomic approaches. Finally, conservation of gene clusters in multiple isolates corroborates the genomic mechanism underlying milk utilization for this infant-associated phylotype.",
keywords = "Carbohydrate metabolism, Co-evolution, Genomics, Human milk oligosaccharides",
author = "Sela, {D. A.} and J. Chapman and A. Adeuya and Kim, {J. H.} and F. Chen and Whitehead, {T. R.} and A. Lapidus and Rokhsar, {D. S.} and Lebrilla, {C. B.} and German, {J. B.} and Price, {N. P.} and Richardson, {P. M.} and Mills, {D. A.}",
year = "2008",
month = dec,
day = "2",
doi = "10.1073/pnas.0809584105",
language = "English",
volume = "105",
pages = "18964--18969",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "48",

}

RIS

TY - JOUR

T1 - The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

AU - Sela, D. A.

AU - Chapman, J.

AU - Adeuya, A.

AU - Kim, J. H.

AU - Chen, F.

AU - Whitehead, T. R.

AU - Lapidus, A.

AU - Rokhsar, D. S.

AU - Lebrilla, C. B.

AU - German, J. B.

AU - Price, N. P.

AU - Richardson, P. M.

AU - Mills, D. A.

PY - 2008/12/2

Y1 - 2008/12/2

N2 - Following birth, the breast-fed infant gastrointestinal tract is rapidly colonized by a microbial consortium often dominated by bifidobacteria. Accordingly, the complete genome sequence of Bifidobacterium longum subsp. infantis ATCC15697 reflects a competitive nutrient-utilization strategy targeting milk-borne molecules which lack a nutritive value to the neonate. Several chromosomal loci reflect potential adaptation to the infant host including a 43 kbp cluster encoding catabolic genes, extracellular solute binding proteins and permeases predicted to be active on milk oligosaccharides. An examination of in vivo metabolism has detected the hallmarks of milk oligosaccharide utilization via the central fermentative pathway using metabolomic and proteomic approaches. Finally, conservation of gene clusters in multiple isolates corroborates the genomic mechanism underlying milk utilization for this infant-associated phylotype.

AB - Following birth, the breast-fed infant gastrointestinal tract is rapidly colonized by a microbial consortium often dominated by bifidobacteria. Accordingly, the complete genome sequence of Bifidobacterium longum subsp. infantis ATCC15697 reflects a competitive nutrient-utilization strategy targeting milk-borne molecules which lack a nutritive value to the neonate. Several chromosomal loci reflect potential adaptation to the infant host including a 43 kbp cluster encoding catabolic genes, extracellular solute binding proteins and permeases predicted to be active on milk oligosaccharides. An examination of in vivo metabolism has detected the hallmarks of milk oligosaccharide utilization via the central fermentative pathway using metabolomic and proteomic approaches. Finally, conservation of gene clusters in multiple isolates corroborates the genomic mechanism underlying milk utilization for this infant-associated phylotype.

KW - Carbohydrate metabolism

KW - Co-evolution

KW - Genomics

KW - Human milk oligosaccharides

UR - http://www.scopus.com/inward/record.url?scp=57749113201&partnerID=8YFLogxK

U2 - 10.1073/pnas.0809584105

DO - 10.1073/pnas.0809584105

M3 - Article

C2 - 19033196

AN - SCOPUS:57749113201

VL - 105

SP - 18964

EP - 18969

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 48

ER -

ID: 90034239