The effect of the chain length of polynucleotides on their binding with platinum complexes

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The effect of the chain length of polynucleotides on their binding with platinum complexes. / Stefanov, V. E.; Tulub, A. A.; Kutin, A. A.

в: International Journal of Biological Macromolecules, Том 26, № 2-3, 11.1999, стр. 161-166.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Stefanov, V. E. ; Tulub, A. A. ; Kutin, A. A. / The effect of the chain length of polynucleotides on their binding with platinum complexes. в: International Journal of Biological Macromolecules. 1999 ; Том 26, № 2-3. стр. 161-166.

BibTeX

@article{943f8d0344a24bef85bf11544f1450e0,

title = "The effect of the chain length of polynucleotides on their binding with platinum complexes",

abstract = "The effect of the length of polynucleotides on their binding with platinum complexes was studied. The highest reaction rate was observed in the reaction with guanosine-containing polynucleotides, whereas cytidine- and adenosine-containing polynucleotides were much less efficient. The monoaqua-forms of the platinum complexes exhibited the highest reactivity in the interaction with polynucleotides in solution. The mechanism implies the formation of the monodentate complex at the first stage which is transformed into the corresponding bidentate complex of chelate type at the second stage. Increase in the length of the polynucleotide chain was shown to enhance its interaction with the platinum complexes. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Binding to platinum complexes, Polynucleotide chain length",

author = "Stefanov, {V. E.} and Tulub, {A. A.} and Kutin, {A. A.}",

note = "Funding Information: The authors are grateful to Dr P. Snezhich for useful discussions. This work was supported by a research grant from the Russian Foundation for Basic Research (RFFI). ",

year = "1999",

month = nov,

doi = "10.1016/S0141-8130(99)00077-X",

language = "English",

volume = "26",

pages = "161--166",

journal = "International Journal of Biological Macromolecules",

issn = "0141-8130",

publisher = "Elsevier",

number = "2-3",

}

RIS

TY - JOUR

T1 - The effect of the chain length of polynucleotides on their binding with platinum complexes

AU - Stefanov, V. E.

AU - Tulub, A. A.

AU - Kutin, A. A.

N1 - Funding Information: The authors are grateful to Dr P. Snezhich for useful discussions. This work was supported by a research grant from the Russian Foundation for Basic Research (RFFI).

PY - 1999/11

Y1 - 1999/11

N2 - The effect of the length of polynucleotides on their binding with platinum complexes was studied. The highest reaction rate was observed in the reaction with guanosine-containing polynucleotides, whereas cytidine- and adenosine-containing polynucleotides were much less efficient. The monoaqua-forms of the platinum complexes exhibited the highest reactivity in the interaction with polynucleotides in solution. The mechanism implies the formation of the monodentate complex at the first stage which is transformed into the corresponding bidentate complex of chelate type at the second stage. Increase in the length of the polynucleotide chain was shown to enhance its interaction with the platinum complexes. Copyright (C) 1999 Elsevier Science B.V.

AB - The effect of the length of polynucleotides on their binding with platinum complexes was studied. The highest reaction rate was observed in the reaction with guanosine-containing polynucleotides, whereas cytidine- and adenosine-containing polynucleotides were much less efficient. The monoaqua-forms of the platinum complexes exhibited the highest reactivity in the interaction with polynucleotides in solution. The mechanism implies the formation of the monodentate complex at the first stage which is transformed into the corresponding bidentate complex of chelate type at the second stage. Increase in the length of the polynucleotide chain was shown to enhance its interaction with the platinum complexes. Copyright (C) 1999 Elsevier Science B.V.

KW - Binding to platinum complexes

KW - Polynucleotide chain length

UR - http://www.scopus.com/inward/record.url?scp=0032861222&partnerID=8YFLogxK

U2 - 10.1016/S0141-8130(99)00077-X

DO - 10.1016/S0141-8130(99)00077-X

M3 - Article

C2 - 10517524

AN - SCOPUS:0032861222

VL - 26

SP - 161

EP - 166

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

SN - 0141-8130

IS - 2-3

ER -

ID: 89841294