TY - JOUR

T1 - The effect of sex and age hormonal changes on the development of heart failure

AU - Serezhina, E. K.

AU - Obrezan, A. G.

N1 - Publisher Copyright: © 2020, Silicea-Poligraf. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - Currently, there is an increase in the incidence of cardiac disease in the elderly. Both the morbidity and progression rate differ in different age and sex groups. Age-related cardiovascular changes can also be associated with the influence of sex hormones both on the myocardium itself and on the signaling involved in the regula-tion of circulation. Estrogen affects the mechanisms of vasodilation, the relationship of hypoxia and angiogenesis, the development of left ventricular diastolic dysfunc-tion. Therefore, estrogen deficiency is a risk factor for cardiovascular diseases. An increase in the androgen level is involved in pathophysiological mechanisms such as aging, heart failure, and vascular remodeling. Many studies have demonstrated the inverse relationship between sex hormone levels and cardiovascular risk, morbidity and mortality. However, efforts to control the natural hormonal changes show mixed results. Addi-tional prospective studies are needed to clarify the roles of various sex hormones in initiating cardiovascular disease and cardiac failure itself, as well as evaluating the effectiveness of hormone therapy in patients with cardiovascular disease.

AB - Currently, there is an increase in the incidence of cardiac disease in the elderly. Both the morbidity and progression rate differ in different age and sex groups. Age-related cardiovascular changes can also be associated with the influence of sex hormones both on the myocardium itself and on the signaling involved in the regula-tion of circulation. Estrogen affects the mechanisms of vasodilation, the relationship of hypoxia and angiogenesis, the development of left ventricular diastolic dysfunc-tion. Therefore, estrogen deficiency is a risk factor for cardiovascular diseases. An increase in the androgen level is involved in pathophysiological mechanisms such as aging, heart failure, and vascular remodeling. Many studies have demonstrated the inverse relationship between sex hormone levels and cardiovascular risk, morbidity and mortality. However, efforts to control the natural hormonal changes show mixed results. Addi-tional prospective studies are needed to clarify the roles of various sex hormones in initiating cardiovascular disease and cardiac failure itself, as well as evaluating the effectiveness of hormone therapy in patients with cardiovascular disease.

KW - Estrogen

KW - Heart failure

KW - Sex and age hormonal changes

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85088293981&partnerID=8YFLogxK

U2 - 10.15829/1560-4071-2020-3710

DO - 10.15829/1560-4071-2020-3710

M3 - Article

AN - SCOPUS:85088293981

VL - 25

SP - 161

EP - 166

JO - РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ

JF - РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ

SN - 1560-4071

IS - 6

ER -