: Cramizol, an imidazole derivative, exhibits lipid-lowering and anti-atherogenic effects. In animals with acute hyperlipidemia induced by Triton WR-1339 cramizol reduced blood levels of cholesterol and triglycerides, and also the atherogenic index. Cramizol and the lipid-lowering drug fenofibrate demonstrated similar effectiveness as hypolipidemic agents. Cramizol also restored the expression of the Apoa1 gene in rats with experimentally induced hyperlipidemia to normal values. This may be a basis of its hypolipidemic and anti-atherogenic action.