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The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton. / Melnitskaya, A. V.; Krutetskaya, Z. I.; Lebedev, O. E.; Butov, S. N.; Krutetskaya, N. I.; Antonov, V. G.

в: Cell and Tissue Biology, Том 6, № 3, 2012, стр. 248-253.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Melnitskaya, AV, Krutetskaya, ZI, Lebedev, OE, Butov, SN, Krutetskaya, NI & Antonov, VG 2012, 'The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton', Cell and Tissue Biology, Том. 6, № 3, стр. 248-253. https://doi.org/10.1134/S1990519X1203008X

APA

Melnitskaya, A. V., Krutetskaya, Z. I., Lebedev, O. E., Butov, S. N., Krutetskaya, N. I., & Antonov, V. G. (2012). The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton. Cell and Tissue Biology, 6(3), 248-253. https://doi.org/10.1134/S1990519X1203008X

Vancouver

Melnitskaya AV, Krutetskaya ZI, Lebedev OE, Butov SN, Krutetskaya NI, Antonov VG. The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton. Cell and Tissue Biology. 2012;6(3):248-253. https://doi.org/10.1134/S1990519X1203008X

Author

Melnitskaya, A. V. ; Krutetskaya, Z. I. ; Lebedev, O. E. ; Butov, S. N. ; Krutetskaya, N. I. ; Antonov, V. G. / The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton. в: Cell and Tissue Biology. 2012 ; Том 6, № 3. стр. 248-253.

BibTeX

@article{b1c181778d17436c995a19cc5f193729,
title = "The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton",
abstract = "Using voltage-clamp technique, the possible role of the cytoskeleton in the effect of pharmacological analogue of oxidized glutathione (GSSG), drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that preincubation of the skin with the microtubular disrupter nocodazole, actin filament disrupter cytochalasin D or protein phosphatase PP1/PP2A inhibitor calyculin A, significantly decrease the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of microtubules and microfilaments in the regulatory effect of glutoxim on Na+ transport in frog skin and that reorganization of actin filaments or microtubules leads to inhibition of stimulatory effect of glutoxim on Na+ transport in frog skin epithelia.",
keywords = "glutoxim, transepithelial Na+ transport, cytoskeleton",
author = "Melnitskaya, {A. V.} and Krutetskaya, {Z. I.} and Lebedev, {O. E.} and Butov, {S. N.} and Krutetskaya, {N. I.} and Antonov, {V. G.}",
year = "2012",
doi = "10.1134/S1990519X1203008X",
language = "English",
volume = "6",
pages = "248--253",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "3",

}

RIS

TY - JOUR

T1 - The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton

AU - Melnitskaya, A. V.

AU - Krutetskaya, Z. I.

AU - Lebedev, O. E.

AU - Butov, S. N.

AU - Krutetskaya, N. I.

AU - Antonov, V. G.

PY - 2012

Y1 - 2012

N2 - Using voltage-clamp technique, the possible role of the cytoskeleton in the effect of pharmacological analogue of oxidized glutathione (GSSG), drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that preincubation of the skin with the microtubular disrupter nocodazole, actin filament disrupter cytochalasin D or protein phosphatase PP1/PP2A inhibitor calyculin A, significantly decrease the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of microtubules and microfilaments in the regulatory effect of glutoxim on Na+ transport in frog skin and that reorganization of actin filaments or microtubules leads to inhibition of stimulatory effect of glutoxim on Na+ transport in frog skin epithelia.

AB - Using voltage-clamp technique, the possible role of the cytoskeleton in the effect of pharmacological analogue of oxidized glutathione (GSSG), drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that preincubation of the skin with the microtubular disrupter nocodazole, actin filament disrupter cytochalasin D or protein phosphatase PP1/PP2A inhibitor calyculin A, significantly decrease the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of microtubules and microfilaments in the regulatory effect of glutoxim on Na+ transport in frog skin and that reorganization of actin filaments or microtubules leads to inhibition of stimulatory effect of glutoxim on Na+ transport in frog skin epithelia.

KW - glutoxim

KW - transepithelial Na+ transport

KW - cytoskeleton

U2 - 10.1134/S1990519X1203008X

DO - 10.1134/S1990519X1203008X

M3 - Article

VL - 6

SP - 248

EP - 253

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 3

ER -

ID: 5379346