The presented study investigated the interrelationship between vegetative regulation and factors of daily stressors in adults. The objective was to determine paths of influence exerted by daily stressors on vegetative regulation in different periods of adulthood. Three hundred forty eight people aged 20-68 years (males – 126, females – 226) participated in the study. In order to calculate vegetative regulation index we used blood pressure levels; readings of the «AngioScan» device designed for assessment of the cardiovascular system condition and electrocardiography (ECG) parameters. Daily stressors were studied using a questionnaire “Daily Stressors” which revealed 10 types of daily stressors. We investigated factors of daily stressors, peculiarities of the vegetative status and stress index in the age groups of early, middle and late adulthood. The paper describes specifics of their manifestation in the age aspect. We revealed prevailing of the dominating type of vegetative index “sympathetic and parasympathetic effects balance” in a sample; parasympathetic effect in the groups of early and middle adulthood and intensified sympathetic effect in late adulthood. When analyzing the path model we found the direct effect of daily
stressors on vegetative regulation and the reverse effect of the age in late adulthood. The study showed a cumulative effect of daily stressors in manifestation of ergotropy. Goodness measure values of the models confirmed their empiric correctness.