Standard

The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages. / Kurilova, L.S.; Krutetskaya, Z.I.; Naumova, A.A.; Butov, S.N.; Krutetskaya, N.I.; Antonov, V.G.

в: Цитология, № 5, 2014, стр. 353-360.

Результаты исследований: Научные публикации в периодических изданиях › статья

Harvard

Kurilova, LS, Krutetskaya, ZI, Naumova, AA, Butov, SN, Krutetskaya, NI & Antonov, VG 2014, 'The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages', Цитология, № 5, стр. 353-360. <http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904555169&origin=inward>

APA

Kurilova, L. S., Krutetskaya, Z. I., Naumova, A. A., Butov, S. N., Krutetskaya, N. I., & Antonov, V. G. (2014). The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages. Цитология, (5), 353-360. http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904555169&origin=inward

Vancouver

Kurilova LS, Krutetskaya ZI, Naumova AA, Butov SN, Krutetskaya NI, Antonov VG. The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages. Цитология. 2014;(5):353-360.

Author

Kurilova, L.S. ; Krutetskaya, Z.I. ; Naumova, A.A. ; Butov, S.N. ; Krutetskaya, N.I. ; Antonov, V.G. / The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages. в: Цитология. 2014 ; № 5. стр. 353-360.

BibTeX

@article{5de99e2da7ee42a3b3e7f4481e61e39d,
title = "The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages",
abstract = "Glutoxim and molixan belong to a new generation of disulfide-containing drugs with immunomodulatory, hepatoprotective and hemopoetic effect. Using Fura-2AM microfluorimetry, the possible involvement of the cyclooxygenase and lipoxygenase pathways of arachidonic acid oxidation in the effect of glutoxim and molixan on the intracellular Ca2+ concentration in rat peritoneal macrophages has been investigated. We have shown for the first time that preincubation of the cells with the cyclooxygenase inhibitors, indomethacin and aspirin, or lipoxygenase inhibitors, nordihydroguaiaretic acid, caffeic acid and baicalein, almost completely prevents the intracellular Ca2+ concentration increase induced by glutoxim or molixan. The obtained data indicate the involvement of products and/or enzymes of the arachidonic acid cyclooxygenase and lipoxygenase metabolism pathways in the effect of glutoxim and molixan on the processes of Ca2+ signaling in macrophages.",
author = "L.S. Kurilova and Z.I. Krutetskaya and A.A. Naumova and S.N. Butov and N.I. Krutetskaya and V.G. Antonov",
year = "2014",
language = "русский",
pages = "353--360",
journal = "Цитология",
issn = "0041-3771",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "5",

}

RIS

TY - JOUR

T1 - The effect of cyclooxygenase and lipoxygenase inhibitors on Ca 2+-responses induced by glutoxim and molixan in macrophages

AU - Kurilova, L.S.

AU - Krutetskaya, Z.I.

AU - Naumova, A.A.

AU - Butov, S.N.

AU - Krutetskaya, N.I.

AU - Antonov, V.G.

PY - 2014

Y1 - 2014

N2 - Glutoxim and molixan belong to a new generation of disulfide-containing drugs with immunomodulatory, hepatoprotective and hemopoetic effect. Using Fura-2AM microfluorimetry, the possible involvement of the cyclooxygenase and lipoxygenase pathways of arachidonic acid oxidation in the effect of glutoxim and molixan on the intracellular Ca2+ concentration in rat peritoneal macrophages has been investigated. We have shown for the first time that preincubation of the cells with the cyclooxygenase inhibitors, indomethacin and aspirin, or lipoxygenase inhibitors, nordihydroguaiaretic acid, caffeic acid and baicalein, almost completely prevents the intracellular Ca2+ concentration increase induced by glutoxim or molixan. The obtained data indicate the involvement of products and/or enzymes of the arachidonic acid cyclooxygenase and lipoxygenase metabolism pathways in the effect of glutoxim and molixan on the processes of Ca2+ signaling in macrophages.

AB - Glutoxim and molixan belong to a new generation of disulfide-containing drugs with immunomodulatory, hepatoprotective and hemopoetic effect. Using Fura-2AM microfluorimetry, the possible involvement of the cyclooxygenase and lipoxygenase pathways of arachidonic acid oxidation in the effect of glutoxim and molixan on the intracellular Ca2+ concentration in rat peritoneal macrophages has been investigated. We have shown for the first time that preincubation of the cells with the cyclooxygenase inhibitors, indomethacin and aspirin, or lipoxygenase inhibitors, nordihydroguaiaretic acid, caffeic acid and baicalein, almost completely prevents the intracellular Ca2+ concentration increase induced by glutoxim or molixan. The obtained data indicate the involvement of products and/or enzymes of the arachidonic acid cyclooxygenase and lipoxygenase metabolism pathways in the effect of glutoxim and molixan on the processes of Ca2+ signaling in macrophages.

M3 - статья

SP - 353

EP - 360

JO - Цитология

JF - Цитология

SN - 0041-3771

IS - 5

ER -

ID: 7049799