Standard

The developing utility of zebrafish models of neurological and neuropsychiatric disorders : A critical review. / Fontana, Barbara D.; Mezzomo, Nathana J.; Kalueff, Allan V.; Rosemberg, Denis B.

в: Experimental Neurology, Том 299, 01.01.2018, стр. 157-171.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Fontana, BD, Mezzomo, NJ, Kalueff, AV & Rosemberg, DB 2018, 'The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review', Experimental Neurology, Том. 299, стр. 157-171. https://doi.org/10.1016/j.expneurol.2017.10.004

APA

Fontana, B. D., Mezzomo, N. J., Kalueff, A. V., & Rosemberg, D. B. (2018). The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review. Experimental Neurology, 299, 157-171. https://doi.org/10.1016/j.expneurol.2017.10.004

Vancouver

Fontana BD, Mezzomo NJ, Kalueff AV, Rosemberg DB. The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review. Experimental Neurology. 2018 Янв. 1;299:157-171. https://doi.org/10.1016/j.expneurol.2017.10.004

Author

Fontana, Barbara D. ; Mezzomo, Nathana J. ; Kalueff, Allan V. ; Rosemberg, Denis B. / The developing utility of zebrafish models of neurological and neuropsychiatric disorders : A critical review. в: Experimental Neurology. 2018 ; Том 299. стр. 157-171.

BibTeX

@article{2cf6d18b80ed40898fcb8b017fed6582,
title = "The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review",
abstract = "Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.",
keywords = "Brain function, Neurological diseases, Neuropsychopharmacology, Psychiatric disorder, Zebrafish",
author = "Fontana, {Barbara D.} and Mezzomo, {Nathana J.} and Kalueff, {Allan V.} and Rosemberg, {Denis B.}",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.expneurol.2017.10.004",
language = "English",
volume = "299",
pages = "157--171",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The developing utility of zebrafish models of neurological and neuropsychiatric disorders

T2 - A critical review

AU - Fontana, Barbara D.

AU - Mezzomo, Nathana J.

AU - Kalueff, Allan V.

AU - Rosemberg, Denis B.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.

AB - Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.

KW - Brain function

KW - Neurological diseases

KW - Neuropsychopharmacology

KW - Psychiatric disorder

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85032361535&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2017.10.004

DO - 10.1016/j.expneurol.2017.10.004

M3 - Review article

AN - SCOPUS:85032361535

VL - 299

SP - 157

EP - 171

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

ER -

ID: 9432679