Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. / Kunst, F.; Ogasawara, N.; Moszer, I.; Albertini, A. M.; Alloni, G.; Azevedo, V.; Bertero, M. G.; Bessières, P.; Bolotin, A.; Borchert, S.; Borriss, R.; Boursier, L.; Brans, A.; Braun, M.; Brignell, S. C.; Bron, S.; Brouillet, S.; Bruschi, C. V.; Caldwell, B.; Capuano, V.; Carter, N. M.; Choi, S. K.; Codani, J. J.; Connerton, I. F.; Cummings, N. J.; Daniel, R. A.; Denizot, F.; Devine, K. M.; Düsterhöft, A.; Ehrlich, S. D.; Emmerson, P. T.; Entian, K. D.; Errington, J.; Fabret, C.; Ferrari, E.; Foulger, D.; Fritz, C.; Fujita, M.; Fujita, Y.; Fuma, S.; Galizzi, A.; Galleron, N.; Ghim, S. Y.; Glaser, P.; Goffeau, A.; Golightly, E. J.; Lapidus, A.; Lee, S. M.; Liu, H.; Sorokin, A.
в: Nature, Том 390, № 6657, 20.11.1997, стр. 249-256.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The complete genome sequence of the gram-positive bacterium Bacillus subtilis
AU - Kunst, F.
AU - Ogasawara, N.
AU - Moszer, I.
AU - Albertini, A. M.
AU - Alloni, G.
AU - Azevedo, V.
AU - Bertero, M. G.
AU - Bessières, P.
AU - Bolotin, A.
AU - Borchert, S.
AU - Borriss, R.
AU - Boursier, L.
AU - Brans, A.
AU - Braun, M.
AU - Brignell, S. C.
AU - Bron, S.
AU - Brouillet, S.
AU - Bruschi, C. V.
AU - Caldwell, B.
AU - Capuano, V.
AU - Carter, N. M.
AU - Choi, S. K.
AU - Codani, J. J.
AU - Connerton, I. F.
AU - Cummings, N. J.
AU - Daniel, R. A.
AU - Denizot, F.
AU - Devine, K. M.
AU - Düsterhöft, A.
AU - Ehrlich, S. D.
AU - Emmerson, P. T.
AU - Entian, K. D.
AU - Errington, J.
AU - Fabret, C.
AU - Ferrari, E.
AU - Foulger, D.
AU - Fritz, C.
AU - Fujita, M.
AU - Fujita, Y.
AU - Fuma, S.
AU - Galizzi, A.
AU - Galleron, N.
AU - Ghim, S. Y.
AU - Glaser, P.
AU - Goffeau, A.
AU - Golightly, E. J.
AU - Lapidus, A.
AU - Lee, S. M.
AU - Liu, H.
AU - Sorokin, A.
PY - 1997/11/20
Y1 - 1997/11/20
N2 - Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete large amounts of industrially important enzymes. Many of the genes are involved in the synthesis of secondary metabolites, including antibiotics, that are more typically associated with Streptomyces species. The genome contains at least ten prophages or remnants of prophages, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.
AB - Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete large amounts of industrially important enzymes. Many of the genes are involved in the synthesis of secondary metabolites, including antibiotics, that are more typically associated with Streptomyces species. The genome contains at least ten prophages or remnants of prophages, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0030731108&partnerID=8YFLogxK
U2 - 10.1038/36786
DO - 10.1038/36786
M3 - Article
C2 - 9384377
AN - SCOPUS:0030731108
VL - 390
SP - 249
EP - 256
JO - Nature
JF - Nature
SN - 0028-0836
IS - 6657
ER -
ID: 39444278