Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The Castagnoli-Cushman reaction in a three-component format. / Chupakhin, Evgeny; Dar'in, Dmitry; Krasavin, Mikhail.
в: Tetrahedron Letters, Том 59, № 26, 27.06.2018, стр. 2595-2599.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The Castagnoli-Cushman reaction in a three-component format
AU - Chupakhin, Evgeny
AU - Dar'in, Dmitry
AU - Krasavin, Mikhail
PY - 2018/6/27
Y1 - 2018/6/27
N2 - The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.
AB - The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.
KW - Azeotropic water removal
KW - Cyclodehydration
KW - Diastereoselectivity
KW - Homophthalic acid
KW - Schiff base
KW - The Castagnoli-Cushman reaction
KW - ONE-POT SYNTHESIS
KW - CATALYST
KW - HOMOPHTHALIC ANHYDRIDE
KW - DICARBOXYLIC-ACIDS
KW - CYCLIC ANHYDRIDES
KW - CONDENSATION
KW - DIVERSITY
KW - CIS-ISOQUINOLONIC ACIDS
KW - INHIBITORS
KW - EFFICIENT
UR - http://www.scopus.com/inward/record.url?scp=85047380284&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2018.05.066
DO - 10.1016/j.tetlet.2018.05.066
M3 - Article
AN - SCOPUS:85047380284
VL - 59
SP - 2595
EP - 2599
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 26
ER -
ID: 34632765