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The Castagnoli-Cushman reaction in a three-component format. / Chupakhin, Evgeny; Dar'in, Dmitry; Krasavin, Mikhail.

в: Tetrahedron Letters, Том 59, № 26, 27.06.2018, стр. 2595-2599.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

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@article{39ae413788ef4d4bba3f8976f5f304cb,
title = "The Castagnoli-Cushman reaction in a three-component format",
abstract = "The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.",
keywords = "Azeotropic water removal, Cyclodehydration, Diastereoselectivity, Homophthalic acid, Schiff base, The Castagnoli-Cushman reaction, ONE-POT SYNTHESIS, CATALYST, HOMOPHTHALIC ANHYDRIDE, DICARBOXYLIC-ACIDS, CYCLIC ANHYDRIDES, CONDENSATION, DIVERSITY, CIS-ISOQUINOLONIC ACIDS, INHIBITORS, EFFICIENT",
author = "Evgeny Chupakhin and Dmitry Dar'in and Mikhail Krasavin",
year = "2018",
month = jun,
day = "27",
doi = "10.1016/j.tetlet.2018.05.066",
language = "English",
volume = "59",
pages = "2595--2599",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "26",

}

RIS

TY - JOUR

T1 - The Castagnoli-Cushman reaction in a three-component format

AU - Chupakhin, Evgeny

AU - Dar'in, Dmitry

AU - Krasavin, Mikhail

PY - 2018/6/27

Y1 - 2018/6/27

N2 - The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.

AB - The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.

KW - Azeotropic water removal

KW - Cyclodehydration

KW - Diastereoselectivity

KW - Homophthalic acid

KW - Schiff base

KW - The Castagnoli-Cushman reaction

KW - ONE-POT SYNTHESIS

KW - CATALYST

KW - HOMOPHTHALIC ANHYDRIDE

KW - DICARBOXYLIC-ACIDS

KW - CYCLIC ANHYDRIDES

KW - CONDENSATION

KW - DIVERSITY

KW - CIS-ISOQUINOLONIC ACIDS

KW - INHIBITORS

KW - EFFICIENT

UR - http://www.scopus.com/inward/record.url?scp=85047380284&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2018.05.066

DO - 10.1016/j.tetlet.2018.05.066

M3 - Article

AN - SCOPUS:85047380284

VL - 59

SP - 2595

EP - 2599

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 26

ER -

ID: 34632765