TY - CONF

T1 - The ART role in TB prevention among people living with HIV (retrospective cohort study)

AU - Zagdyn, Z. M.

AU - Sivacheva, I.

AU - Zverkova, E.

AU - Beltyukov, M. V.

AU - Соколович, Евгений Георгиевич

PY - 2018

Y1 - 2018

N2 - ntiretroviral therapy is one of the most effective strategies for preventing tuberculosis among people living with HIV. It significantly reduces the risk of tuberculosis, regardless of immunosuppression level, results of tuberculin tests and prevalence of drug-resistant tuberculosis in the region. The results of the retrospective cohort study conducted at the Pskov Regional AIDS Center from 2007–2016 convincingly confirmed the importance of the ART in preventing the TB development in patients with HIV. Of the 814 subjects included in the study, 590 – received ART, 305 – did not receive it. In compared groups TB was more likely developed in patients without antiretroviral therapy, RR 0,37 (95% CI 0,20–0,49), they were more likely to die of tuberculosis, RR 0,20 (95% CI 0,065-0,4), and among them more likely occurred other opportunistic diseases, RR 0,53 (95% CI 0,35–0,75). Among those receiving ARVT, tuberculosis and other opportunistic diseases developed more often in individuals with CD4 350 cells/ml, there were no lethal outcomes of tuberculosis, RR 0.23 (95% CI 0.0-2.0).

AB - ntiretroviral therapy is one of the most effective strategies for preventing tuberculosis among people living with HIV. It significantly reduces the risk of tuberculosis, regardless of immunosuppression level, results of tuberculin tests and prevalence of drug-resistant tuberculosis in the region. The results of the retrospective cohort study conducted at the Pskov Regional AIDS Center from 2007–2016 convincingly confirmed the importance of the ART in preventing the TB development in patients with HIV. Of the 814 subjects included in the study, 590 – received ART, 305 – did not receive it. In compared groups TB was more likely developed in patients without antiretroviral therapy, RR 0,37 (95% CI 0,20–0,49), they were more likely to die of tuberculosis, RR 0,20 (95% CI 0,065-0,4), and among them more likely occurred other opportunistic diseases, RR 0,53 (95% CI 0,35–0,75). Among those receiving ARVT, tuberculosis and other opportunistic diseases developed more often in individuals with CD4 350 cells/ml, there were no lethal outcomes of tuberculosis, RR 0.23 (95% CI 0.0-2.0).

KW - HIV-infection, HIV/TB, ARVT

KW - ВИЧ-инфекция, ВИЧ/туберкулез, АРВТ, профилактика туберкулеза среди ВИЧ-положительных людей

M3 - Abstract

SP - 271

EP - 271

T2 - VI Eastern Europe and Central Asia AIDS Conference

Y2 - 18 April 2018 through 20 April 2018

ER -