Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
It has been found that 2-bromo-1,8-bis(dimethylamino)naphthalene on sequential treatment with n-BuLi and 2 equiv of the same or different aryl(hetaryl) cyanide as a result of [2 + 2 + 2] nucleophilic cascade annulation produces 10-dimethylaminobenzo[h]quinazolines, as yet unknown NMe2/-N= analogues of the proton sponge. It is even more convenient to use preliminarily prepared 2-ketimino-1,8-bis(dimethylamino)naphthalenes as starting material. The substitution of both peri-NMe2 groups furnishing quinazolino[7,8-h]quinazoline derivatives is also possible. The process is remarkable by surprisingly mild nucleophilic displacement of an unactivated aromatic NMe2 group.
Язык оригинала | английский |
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Страницы (с-по) | 2872-2875 |
Число страниц | 4 |
Журнал | Organic Letters |
Том | 18 |
Номер выпуска | 12 |
DOI | |
Состояние | Опубликовано - 17 июн 2016 |
ID: 41270767