TY - JOUR

T1 - TAARs Potential Role in Adult Neurogenesis: Narrative Review

AU - Шемякова, Таисия Сергеевна

AU - Петрунина, Евгения Николаевна

PY - 2025/10/1

Y1 - 2025/10/1

N2 - Abstract: Trace amine-associated receptors (TAARs) represent a relatively recently identified family of G-protein coupled receptors that have attracted considerable attention for their potential physiological role in the mammalian brain. TAAR1 is the most extensively studied member of the TAAR family and a promising target for brain diseases therapy. Early research focused on other TAARs (TAAR2–TAAR9) suggested their primary involvement in olfaction. However, more recent studies have revealed their expression in diverse brain regions, including the limbic system and midbrain, implicating them in the regulation of behavior. A growing body of evidence suggests the involvement of several TAAR subtypes in adult neurogenesis, particularly adult hippocampal neurogenesis (AHN), a process critical for memory formation and learning. AHN occurs in the subgranular zone of the dentate gyrus within the hippocampus and generates new excitatory granule cells. The regulatory influence of TAAR1, TAAR2, and TAAR5 subtypes on AHN has been emphasized in several studies. This overview aims to encompass current research findings regarding the role of TAARs in the process of adult neurogenesis.

AB - Abstract: Trace amine-associated receptors (TAARs) represent a relatively recently identified family of G-protein coupled receptors that have attracted considerable attention for their potential physiological role in the mammalian brain. TAAR1 is the most extensively studied member of the TAAR family and a promising target for brain diseases therapy. Early research focused on other TAARs (TAAR2–TAAR9) suggested their primary involvement in olfaction. However, more recent studies have revealed their expression in diverse brain regions, including the limbic system and midbrain, implicating them in the regulation of behavior. A growing body of evidence suggests the involvement of several TAAR subtypes in adult neurogenesis, particularly adult hippocampal neurogenesis (AHN), a process critical for memory formation and learning. AHN occurs in the subgranular zone of the dentate gyrus within the hippocampus and generates new excitatory granule cells. The regulatory influence of TAAR1, TAAR2, and TAAR5 subtypes on AHN has been emphasized in several studies. This overview aims to encompass current research findings regarding the role of TAARs in the process of adult neurogenesis.

KW - adult neurogenesis

KW - hippocampus

KW - neuropsychiatric disorders

KW - subgranular zone

KW - trace amine-associated receptors

UR - https://www.mendeley.com/catalogue/002db13e-0c56-33c2-bb68-ae2c967660db/

U2 - 10.1134/S1990519X25600309

DO - 10.1134/S1990519X25600309

M3 - Article

VL - 19

SP - 422

EP - 430

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 5

ER -