TY - JOUR

T1 - TAAR5 receptor agonist affects sensory gating in rats

AU - Александров, Александр Алексеевич

AU - Дмитриева, Елена Сергеевна

AU - Вольнова, Анна Борисовна

AU - Князева, Вероника Михайловна

AU - Герасимов, Андрей Сергеевич

AU - Гайнетдинов, Рауль Радикович

N1 - Funding Information: This work was supported by the Russian Foundation of Basic Research (grant number 17-04-00082 ) to AAA; and the Russian Science Foundation (grant number 14-50-00069 ) to RRG and AG.

PY - 2018/2/14

Y1 - 2018/2/14

N2 - Trace amines are structurally close to classical monoamines and dysregulation in trace amines and/or their receptors might contribute to pathology of mental disorders. The study was aimed to investigate the effect of recently identified Trace Amine-Associated Receptor 5 (TAAR5) agonist 2-(alpha-naphthoyl)ethyltrimethylammonium iodide (alpha-NETA) on sensory gating (SG) in awake freely moving rats. SG was studied in paired-click paradigm and SG index was calculated as difference in event related potentials component N40 amplitudes to the first and second stimulus in the pair. The 1 mg/kg dose of alpha-NETA as well as the control injection of saline had no significant effects on the SG index. However, higher doses of alpha-NETA (3 and 5 mg/kg) significantly decreased the SG index. The change in the SG index was mainly due to a decrease in the N40 amplitude, and the 5 mg/kg dose caused the N40 decrease both in response to the first and second stimulus in the pair. Thus, TAAR5 activation can influence SG, indicating the potential role of trace amines and TAAR5 in sensory information dosing.

AB - Trace amines are structurally close to classical monoamines and dysregulation in trace amines and/or their receptors might contribute to pathology of mental disorders. The study was aimed to investigate the effect of recently identified Trace Amine-Associated Receptor 5 (TAAR5) agonist 2-(alpha-naphthoyl)ethyltrimethylammonium iodide (alpha-NETA) on sensory gating (SG) in awake freely moving rats. SG was studied in paired-click paradigm and SG index was calculated as difference in event related potentials component N40 amplitudes to the first and second stimulus in the pair. The 1 mg/kg dose of alpha-NETA as well as the control injection of saline had no significant effects on the SG index. However, higher doses of alpha-NETA (3 and 5 mg/kg) significantly decreased the SG index. The change in the SG index was mainly due to a decrease in the N40 amplitude, and the 5 mg/kg dose caused the N40 decrease both in response to the first and second stimulus in the pair. Thus, TAAR5 activation can influence SG, indicating the potential role of trace amines and TAAR5 in sensory information dosing.

KW - рецепторы следовых аминов

KW - TAAR5

KW - 2-(alpha-naphthoyl)ethyltrimethylammonium iodide

KW - сенсорный гейтинг

KW - N40

KW - 2-(alpha-naphthoyl)ethyltrimethylammonium iodide (alpha-NETA)

KW - Awake rat

KW - N40

KW - Sensory gating

KW - TAAR5

KW - Trace amine associated receptors

KW - SCHIZOPHRENIA

KW - SCHIZOTYPAL PERSONALITY-DISORDER

KW - MODEL

KW - HIPPOCAMPUS

KW - GENE

KW - ANTAGONISTS

KW - DEFICITS

KW - AMPHETAMINE

KW - P50 SUPPRESSION

UR - http://www.scopus.com/inward/record.url?scp=85039730901&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/taar5-receptor-agonist-affects-sensory-gating-rats

U2 - 10.1016/j.neulet.2017.12.053

DO - 10.1016/j.neulet.2017.12.053

M3 - Article

VL - 666

SP - 144

EP - 147

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -