Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Previously unknown N-aminosaccharin was prepared in good yield via the one-step direct amination of saccharin sodium salt with hydroxylamine-O-mesitylenesulfonic acid (MSH) and its reactivity investigated. N-aminosaccharin and its derivatives were tested against hCA isoforms and the parent compound was identified to be a selective, low micromolar inhibitor (Ki= 8.8 μM) of hCA I. These findings provide a ligand-efficient starting point for the design of potent hCA I inhibitors – a promising drug target for retinal/cerebral edema treatment.
Язык оригинала | английский |
---|---|
Страницы (с-по) | 172-174 |
Число страниц | 3 |
Журнал | Tetrahedron Letters |
Том | 58 |
Номер выпуска | 2 |
DOI | |
Состояние | Опубликовано - 2017 |
ID: 7738897