TY - JOUR

T1 - Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives

AU - Popova, E. A.

AU - Mikolaichuk, O. V.

AU - Protas, A. V.

AU - Mukhametshina, A. V.

AU - Ovsepyan, G. K.

AU - Starova, G. L.

AU - Suezov, R. V.

AU - Fonin, A. V.

AU - Trifonov, R. E.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–{1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.

AB - A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–{1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.

KW - antiproliferative activity

KW - interaction with DNA

KW - tetrazol-2-ylacetic acid derivatives

KW - tetrazole-containing Pd(II) complexes

UR - http://www.scopus.com/inward/record.url?scp=85059190973&partnerID=8YFLogxK

U2 - 10.1134/S1070363218110178

DO - 10.1134/S1070363218110178

M3 - Article

AN - SCOPUS:85059190973

VL - 88

SP - 2354

EP - 2358

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - 11

ER -