Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A transition-metal-free postmodification of the Groebke-Blackburn-Bienaymé (GBB) reaction for the synthesis of spiro[chromene-imidazo[1,2-A]pyridin]-3′-imine was discovered. The unusual transformation represents the first example of activation and the reaction of the imidazole carbon atom. In this postcondensational modification, KOt-Bu acts as a base, which, after the isomerization of an alkyne moiety to allene, causes the next unique nucleophilic reaction of the imidazole carbon atom that results in spirocyclic structures. The proposed reaction mechanism was confirmed based on the DFT calculations.
Язык оригинала | английский |
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Страницы (с-по) | 13693–13701 |
Число страниц | 9 |
Журнал | Journal of Organic Chemistry |
Том | 86 |
Номер выпуска | 19 |
DOI | |
Состояние | Опубликовано - 1 окт 2021 |
ID: 86412774