Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis of Selenium-Containing Chitosan Derivatives and Their Antibacterial Activity. / Егоров, А.Р.; Артемьев, А.А.; Козырев, В.А.; Сикаона, Д.Н.; Рубаник, В.В.; Рубаник (мл.), В.В.; Критченков, Илья Сергеевич; Ягафаров, Н.З.; Хубиев, О.М.; Терешина, Т.А.; Култышкина, Е.К.; Меджбур, Б.; Хрусталев, В.Н.; Критченков, А.С.
в: Applied Biochemistry and Microbiology, Том 58, № 2, 04.2022, стр. 132-135.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis of Selenium-Containing Chitosan Derivatives and Their Antibacterial Activity
AU - Егоров, А.Р.
AU - Артемьев, А.А.
AU - Козырев, В.А.
AU - Сикаона, Д.Н.
AU - Рубаник, В.В.
AU - Рубаник (мл.), В.В.
AU - Критченков, Илья Сергеевич
AU - Ягафаров, Н.З.
AU - Хубиев, О.М.
AU - Терешина, Т.А.
AU - Култышкина, Е.К.
AU - Меджбур, Б.
AU - Хрусталев, В.Н.
AU - Критченков, А.С.
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022/4
Y1 - 2022/4
N2 - Abstract: The interaction of chitosan with 3-(chloromethyl)-[1,2,4]selendiazole[4,5-a]pyridin-4 bromide results in water-soluble, selenium-containing, cationic chitosan derivatives. Derivatives of chitosan with degrees of substitution of 0.15, 0.45, and 0.65 were obtained. These derivatives are characterized by a pronounced in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli, and the antibacterial activity of the derivatives increases with an increase in their degree of substitution. The antibacterial activity of the highly substituted derivative is comparable to that of the conventional antibiotics ampicillin and gentamicin.
AB - Abstract: The interaction of chitosan with 3-(chloromethyl)-[1,2,4]selendiazole[4,5-a]pyridin-4 bromide results in water-soluble, selenium-containing, cationic chitosan derivatives. Derivatives of chitosan with degrees of substitution of 0.15, 0.45, and 0.65 were obtained. These derivatives are characterized by a pronounced in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli, and the antibacterial activity of the derivatives increases with an increase in their degree of substitution. The antibacterial activity of the highly substituted derivative is comparable to that of the conventional antibiotics ampicillin and gentamicin.
KW - antibacterial activity
KW - chitosan
KW - heterocycles
KW - selenium
UR - http://www.scopus.com/inward/record.url?scp=85127166890&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/eda917c4-23db-3542-8ff2-1a8a91a7541e/
U2 - 10.1134/S0003683822020053
DO - 10.1134/S0003683822020053
M3 - Article
VL - 58
SP - 132
EP - 135
JO - Applied Biochemistry and Microbiology
JF - Applied Biochemistry and Microbiology
SN - 0003-6838
IS - 2
ER -
ID: 96211907