DOI

  • P. A. Zhmurov
  • A. A. Tabolin
  • A. Yu Sukhorukov
  • A. V. Lesiv
  • M. S. Klenov
  • Yu A. Khomutova
  • S. L. Ioffe
  • V. A. Tartakovsky

The total stereoselective synthesis of two highly potent phosphodiesterase IVb inhibitors from nitroethane, isovanillin, and ethyl vinyl ether was developed. The compounds obtained are the derivatives of hexahydro-3H-pyrrolo[1, 2-c]imidazol-3-one and tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one. The strategy proposed involves silylation of six-membered cyclic nitronates as a key step leading to 5,6-dihydro-4H-1,2-oxazines with the group CH 2FG (FG = N 3 or OH) at the C(3) atom.

Язык оригиналаанглийский
Страницы (с-по)2390-2395
Число страниц6
ЖурналRussian Chemical Bulletin
Том60
Номер выпуска11
DOI
СостояниеОпубликовано - 1 ноя 2011

    Предметные области Scopus

  • Химия (все)

ID: 62819051