A flexible method was developed for the synthesis of
2,2′-bi-, 2,2′:6′,2″-ter-, and 2,2′:6′,2′′:6′′,2‴-quaterpyridines con-
taining a nicotinic acid moiety. The approach involves the Fe(II)/
Au(I)-catalyzed rearrangement of key 4-propargylisoxazole build-
ing blocks bearing a pyrid-2-yl or quinolin-2-yl substituent at the 3- position and Pd(0)-catalyzed cross-coupling reactions.