Standard

Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin. / Navidi, Mozhgan; Yadav, Shreya; Struts, Andrey V.; Brown, Michael F.; Nesnas, Nasri.

в: Tetrahedron Letters, Том 59, № 51, 19.12.2018, стр. 4521-4524.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Navidi, M, Yadav, S, Struts, AV, Brown, MF & Nesnas, N 2018, 'Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin', Tetrahedron Letters, Том. 59, № 51, стр. 4521-4524. https://doi.org/10.1016/j.tetlet.2018.11.034

APA

Navidi, M., Yadav, S., Struts, A. V., Brown, M. F., & Nesnas, N. (2018). Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin. Tetrahedron Letters, 59(51), 4521-4524. https://doi.org/10.1016/j.tetlet.2018.11.034

Vancouver

Navidi M, Yadav S, Struts AV, Brown MF, Nesnas N. Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin. Tetrahedron Letters. 2018 Дек. 19;59(51):4521-4524. https://doi.org/10.1016/j.tetlet.2018.11.034

Author

Navidi, Mozhgan ; Yadav, Shreya ; Struts, Andrey V. ; Brown, Michael F. ; Nesnas, Nasri. / Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin. в: Tetrahedron Letters. 2018 ; Том 59, № 51. стр. 4521-4524.

BibTeX

@article{181266a300184b409e9b0a0c4b0348a1,
title = "Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin",
abstract = "We report the synthesis of 9-CD3-9-cis-retinal via a six-step procedure from β-ionone. The steps involve an initial deuteration of the methyl ketone of β-ionone followed by two consecutive Horner-Wadsworth-Emmons (HWE) coupling reactions and their corresponding DIBAL reductions. A final oxidation of the allylic alcohol of the retinol leads to the target compound. This deuterium labeled retinoid is an important cofactor for studying protein-retinoid interactions in isorhodopsin.",
keywords = "9-CD-9-cis-retinal, Isorhodopsin, Labeled retinal, Retinoids, Rhodopsin, LOCATION, CHROMOPHORE, ISOMERIZATION, NEUTRON-DIFFRACTION, EFFICIENT SYNTHESIS, 9-CD3-9-cis-retinal, RHODOPSIN, DYNAMICS, H-2 NMR, STEREOSELECTIVE-SYNTHESIS, VISUAL PIGMENT",
author = "Mozhgan Navidi and Shreya Yadav and Struts, {Andrey V.} and Brown, {Michael F.} and Nasri Nesnas",
year = "2018",
month = dec,
day = "19",
doi = "10.1016/j.tetlet.2018.11.034",
language = "English",
volume = "59",
pages = "4521--4524",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "51",

}

RIS

TY - JOUR

T1 - Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin

AU - Navidi, Mozhgan

AU - Yadav, Shreya

AU - Struts, Andrey V.

AU - Brown, Michael F.

AU - Nesnas, Nasri

PY - 2018/12/19

Y1 - 2018/12/19

N2 - We report the synthesis of 9-CD3-9-cis-retinal via a six-step procedure from β-ionone. The steps involve an initial deuteration of the methyl ketone of β-ionone followed by two consecutive Horner-Wadsworth-Emmons (HWE) coupling reactions and their corresponding DIBAL reductions. A final oxidation of the allylic alcohol of the retinol leads to the target compound. This deuterium labeled retinoid is an important cofactor for studying protein-retinoid interactions in isorhodopsin.

AB - We report the synthesis of 9-CD3-9-cis-retinal via a six-step procedure from β-ionone. The steps involve an initial deuteration of the methyl ketone of β-ionone followed by two consecutive Horner-Wadsworth-Emmons (HWE) coupling reactions and their corresponding DIBAL reductions. A final oxidation of the allylic alcohol of the retinol leads to the target compound. This deuterium labeled retinoid is an important cofactor for studying protein-retinoid interactions in isorhodopsin.

KW - 9-CD-9-cis-retinal

KW - Isorhodopsin

KW - Labeled retinal

KW - Retinoids

KW - Rhodopsin

KW - LOCATION

KW - CHROMOPHORE

KW - ISOMERIZATION

KW - NEUTRON-DIFFRACTION

KW - EFFICIENT SYNTHESIS

KW - 9-CD3-9-cis-retinal

KW - RHODOPSIN

KW - DYNAMICS

KW - H-2 NMR

KW - STEREOSELECTIVE-SYNTHESIS

KW - VISUAL PIGMENT

UR - http://www.scopus.com/inward/record.url?scp=85056473566&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2018.11.034

DO - 10.1016/j.tetlet.2018.11.034

M3 - Article

AN - SCOPUS:85056473566

VL - 59

SP - 4521

EP - 4524

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 51

ER -

ID: 36383372