Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A method for the synthesis of densely substituted 4-pyrrolin-2-ones by Rh(II)-catalyzed denitrogenative transannulation of 1-alkyl-4-aryl-1H-1,2,3-triazoles with diazo esters has been developed. The reaction proceeds via an attack of the rhodium-bound carbene at the N2 atom of the triazole and the formation of unstable 3,4-dihydro-1,2,4-triazine, which further undergoes ring contraction to a 4-pyrrolin-2-one under rhodium catalysis. The method is inapplicable to 1,2,3-triazoles with primary alkyl substituent at C4, which afford stable 1,2,3-triazol-3-ium ylides as the main products.
Язык оригинала | английский |
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Страницы (с-по) | 7958–7963 |
Число страниц | 6 |
Журнал | Organic Letters |
Том | 22 |
Номер выпуска | 20 |
DOI | |
Состояние | Опубликовано - 16 окт 2020 |
ID: 70360850