Standard

Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents. / Ellis, Beverley L.; Gorshkov, Nikolay I.; Lumpov, Alexander A.; Miroslavov, Alexander E.; Yalfimov, Anatoly N.; Gurzhiy, Vladislav V.; Suglobov, Dmitrii N.; Braddock, Rattana; Adams, Joanne C.; Smith, Anne-Marie; Prescott, Mary C.; Sharma, Harbans L.

в: Journal of Labelled Compounds and Radiopharmaceuticals, Том 56, № 14, 2013, стр. 700-707.

Результаты исследований: Научные публикации в периодических изданиях › статья

Harvard

Ellis, BL, Gorshkov, NI, Lumpov, AA, Miroslavov, AE, Yalfimov, AN, Gurzhiy, VV, Suglobov, DN, Braddock, R, Adams, JC, Smith, A-M, Prescott, MC & Sharma, HL 2013, 'Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents', Journal of Labelled Compounds and Radiopharmaceuticals, Том. 56, № 14, стр. 700-707. https://doi.org/10.1002/jlcr.3106

APA

Ellis, B. L., Gorshkov, N. I., Lumpov, A. A., Miroslavov, A. E., Yalfimov, A. N., Gurzhiy, V. V., Suglobov, D. N., Braddock, R., Adams, J. C., Smith, A-M., Prescott, M. C., & Sharma, H. L. (2013). Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents. Journal of Labelled Compounds and Radiopharmaceuticals, 56(14), 700-707. https://doi.org/10.1002/jlcr.3106

Vancouver

Ellis BL, Gorshkov NI, Lumpov AA, Miroslavov AE, Yalfimov AN, Gurzhiy VV и пр. Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents. Journal of Labelled Compounds and Radiopharmaceuticals. 2013;56(14):700-707. https://doi.org/10.1002/jlcr.3106

Author

Ellis, Beverley L. ; Gorshkov, Nikolay I. ; Lumpov, Alexander A. ; Miroslavov, Alexander E. ; Yalfimov, Anatoly N. ; Gurzhiy, Vladislav V. ; Suglobov, Dmitrii N. ; Braddock, Rattana ; Adams, Joanne C. ; Smith, Anne-Marie ; Prescott, Mary C. ; Sharma, Harbans L. / Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents. в: Journal of Labelled Compounds and Radiopharmaceuticals. 2013 ; Том 56, № 14. стр. 700-707.

BibTeX

@article{9f9e2ed6199c46b38d093412b146ecbc,
title = "Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents",
abstract = "Myocardial perfusion imaging is an established Nuclear Medicine investigation. Current myocardial perfusion imaging agents sestamibi and tetrofosmin have number of drawbacks; low heart uptake coupled with uptake into the surrounding tissues leads to a poorer image quality. There is a need for continued research into designing and evaluating potentially superior myocardial imaging agents. Tri-carbonyl-technetium and rhenium complexes were prepared by combination with mono-dentate and bi-dentate ligands. Complexes were characterized by HPLC, MAS, nuclear magnetic resonance, infrared, single-crystal X-ray diffraction and partition coefficient determinations. Tc-99m(CO)(3) complexes were administered intravenously to Sprague Dawley rats, and tissue distribution studies were carried out at 15min and 1h p.i. Radiochemical purity was assessed as >90%. 1-10-phenanthroline, 2,2-bipyridine and imidazole complexes gave the highest heart uptake. The percentage injected dose per gram (n=3) at 1h for 1-10-phenanthroline/im",
author = "Ellis, {Beverley L.} and Gorshkov, {Nikolay I.} and Lumpov, {Alexander A.} and Miroslavov, {Alexander E.} and Yalfimov, {Anatoly N.} and Gurzhiy, {Vladislav V.} and Suglobov, {Dmitrii N.} and Rattana Braddock and Adams, {Joanne C.} and Anne-Marie Smith and Prescott, {Mary C.} and Sharma, {Harbans L.}",
year = "2013",
doi = "10.1002/jlcr.3106",
language = "English",
volume = "56",
pages = "700--707",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "Wiley-Blackwell",
number = "14",

}

RIS

TY - JOUR

T1 - Synthesis, characterization and pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion imaging agents

AU - Ellis, Beverley L.

AU - Gorshkov, Nikolay I.

AU - Lumpov, Alexander A.

AU - Miroslavov, Alexander E.

AU - Yalfimov, Anatoly N.

AU - Gurzhiy, Vladislav V.

AU - Suglobov, Dmitrii N.

AU - Braddock, Rattana

AU - Adams, Joanne C.

AU - Smith, Anne-Marie

AU - Prescott, Mary C.

AU - Sharma, Harbans L.

PY - 2013

Y1 - 2013

N2 - Myocardial perfusion imaging is an established Nuclear Medicine investigation. Current myocardial perfusion imaging agents sestamibi and tetrofosmin have number of drawbacks; low heart uptake coupled with uptake into the surrounding tissues leads to a poorer image quality. There is a need for continued research into designing and evaluating potentially superior myocardial imaging agents. Tri-carbonyl-technetium and rhenium complexes were prepared by combination with mono-dentate and bi-dentate ligands. Complexes were characterized by HPLC, MAS, nuclear magnetic resonance, infrared, single-crystal X-ray diffraction and partition coefficient determinations. Tc-99m(CO)(3) complexes were administered intravenously to Sprague Dawley rats, and tissue distribution studies were carried out at 15min and 1h p.i. Radiochemical purity was assessed as >90%. 1-10-phenanthroline, 2,2-bipyridine and imidazole complexes gave the highest heart uptake. The percentage injected dose per gram (n=3) at 1h for 1-10-phenanthroline/im

AB - Myocardial perfusion imaging is an established Nuclear Medicine investigation. Current myocardial perfusion imaging agents sestamibi and tetrofosmin have number of drawbacks; low heart uptake coupled with uptake into the surrounding tissues leads to a poorer image quality. There is a need for continued research into designing and evaluating potentially superior myocardial imaging agents. Tri-carbonyl-technetium and rhenium complexes were prepared by combination with mono-dentate and bi-dentate ligands. Complexes were characterized by HPLC, MAS, nuclear magnetic resonance, infrared, single-crystal X-ray diffraction and partition coefficient determinations. Tc-99m(CO)(3) complexes were administered intravenously to Sprague Dawley rats, and tissue distribution studies were carried out at 15min and 1h p.i. Radiochemical purity was assessed as >90%. 1-10-phenanthroline, 2,2-bipyridine and imidazole complexes gave the highest heart uptake. The percentage injected dose per gram (n=3) at 1h for 1-10-phenanthroline/im

U2 - 10.1002/jlcr.3106

DO - 10.1002/jlcr.3106

M3 - Article

VL - 56

SP - 700

EP - 707

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 14

ER -

ID: 7405504