TY - JOUR

T1 - Synthesis, characterisation and biocompatibility of graphene–L-methionine nanomaterial

AU - Abdelhalim, Abdelsattar O.E.

AU - Sharoyko, Vladimir V.

AU - Meshcheriakov, Anatolii A.

AU - Luttsev, Michail D.

AU - Potanin, Artem A.

AU - Iamalova, Nailia R.

AU - Zakharov, Egor E.

AU - Ageev, Sergei V.

AU - Petrov, Andrey V.

AU - Vasina, Lubov V.

AU - Solovtsova, Irina L.

AU - Nashchekin, Alexei V.

AU - Murin, Igor V.

AU - Semenov, Konstantin N.

N1 - Funding Information: The work was supported by the Grant of the Russian Foundation for Basic Research ( 19-315-90122 ) and by the Grant of the Council on grants of the President of the Russian Federation for young scientists ( MD-741.2020.7 ). Research was performed using the equipment of the Resource Centre “GeoModel”, Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Magnetic Resonance Research Centre, Centre for Physical Methods of Surface Investigation; computational resources provided by Resource Centre “Computer Centre of SPbU” and Centre for Chemical Analysis and Materials Research of the Research Park of Saint Petersburg State University. SEM characterisation was performed using equipment of the Federal Joint Research Centre “Material Science and Characterisation in Advanced Technology”. Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/9/15

Y1 - 2020/9/15

N2 - The article presents data on synthesis, identification, computer modelling and biocompatibility of graphene oxide functionalised with L-methionine (GFM). In the framework of our research, graphene oxide synthesised using Hammers' method was modified through amidation reaction. The characterisation of the compound was performed using various physicochemical techniques, such as X-ray diffraction, X-ray photoelectron spectroscopy, infrared, Raman spectroscopy, thermogravimetric analysis, scanning electron microscopy, and high-resolution transmission electron microscopy. Investigation of biocompatibility included experiments on erythrocytes haemolysis, platelet aggregation, photodynamic and antiradical activity studies, binding to human serum albumin, geno- and cytotoxicity. Moreover, using density functional theory and molecular dynamics approaches, structural and dynamic characteristics of a GFM–water binary system were obtained.

AB - The article presents data on synthesis, identification, computer modelling and biocompatibility of graphene oxide functionalised with L-methionine (GFM). In the framework of our research, graphene oxide synthesised using Hammers' method was modified through amidation reaction. The characterisation of the compound was performed using various physicochemical techniques, such as X-ray diffraction, X-ray photoelectron spectroscopy, infrared, Raman spectroscopy, thermogravimetric analysis, scanning electron microscopy, and high-resolution transmission electron microscopy. Investigation of biocompatibility included experiments on erythrocytes haemolysis, platelet aggregation, photodynamic and antiradical activity studies, binding to human serum albumin, geno- and cytotoxicity. Moreover, using density functional theory and molecular dynamics approaches, structural and dynamic characteristics of a GFM–water binary system were obtained.

KW - Biocompatibility; Graphene oxide; HSA; L-methionine; Molecular dynamics; Radachlorin

KW - Graphene oxide

KW - L-methionine

KW - Biocompatibility

KW - Radachlorin

KW - HSA

KW - Molecular dynamics

KW - OXIDE NANOSHEETS

KW - SERUM-ALBUMIN

KW - SUPERIOR

KW - FUNCTIONALIZATION

KW - CYTOTOXICITY

KW - GENOTOXICITY

UR - http://www.scopus.com/inward/record.url?scp=85087402693&partnerID=8YFLogxK

U2 - 10.1016/j.molliq.2020.113605

DO - 10.1016/j.molliq.2020.113605

M3 - Article

AN - SCOPUS:85087402693

VL - 314

SP - 113605

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

M1 - 113605

ER -