TY - JOUR

T1 - Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids

AU - Tarasenko, M. V.

AU - Presnukhina, S. I.

AU - Baikov, S. V.

AU - Shetnev, A. A.

N1 - Funding Information: This work was financially supported by the Russian Foundation for Basic Research (project no. 19-33-60064) using the equipment of the Resource Centers “Chemical Analysis and Materials Research Center” and “Magnetic Resonance Research Center” of the Research Park of St. Petersburg State University. Publisher Copyright: © 2020, Pleiades Publishing, Ltd. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Abstract: A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus.

AB - Abstract: A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus.

KW - amidoximes

KW - antimicrobial activity

KW - basic catalysis

KW - dicarboxylic acid anhydrides

KW - heterocycles

KW - DESIGN

KW - ONE-POT SYNTHESIS

KW - PERIPHERY

KW - OXADIAZOLE CLASS

KW - ANTIBIOTIC-RESISTANCE

KW - COMBINATION

KW - IN-VITRO

KW - DOUBLE-BLIND

KW - INHIBITORS

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=85092405759&partnerID=8YFLogxK

U2 - 10.1134/S1070363220090042

DO - 10.1134/S1070363220090042

M3 - Article

AN - SCOPUS:85092405759

VL - 90

SP - 1611

EP - 1619

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - 9

ER -