TY - JOUR

T1 - Synchronization of the Processes of Autonomic Control of Blood Circulation in Humans Is Different in the Awake State and in Sleep Stages

AU - Karavaev, Anatoly S.

AU - Skazkina, Viktoriia V.

AU - Borovkova, Ekaterina I.

AU - Prokhorov, Mikhail D.

AU - Hramkov, Aleksey N.

AU - Ponomarenko, Vladimir I.

AU - Runnova, Anastasiya E.

AU - Gridnev, Vladimir I.

AU - Kiselev, Anton R.

AU - Kuznetsov, Nikolay V.

AU - Chechurin, Leonid S.

AU - Penzel, Thomas

N1 - Publisher Copyright: Copyright © 2022 Karavaev, Skazkina, Borovkova, Prokhorov, Hramkov, Ponomarenko, Runnova, Gridnev, Kiselev, Kuznetsov, Chechurin and Penzel.

PY - 2022/1/12

Y1 - 2022/1/12

N2 - The influence of higher nervous activity on the processes of autonomic control of the cardiovascular system and baroreflex regulation is of considerable interest, both for understanding the fundamental laws of the functioning of the human body and for developing methods for diagnostics and treatment of pathologies. The complexity of the analyzed systems limits the possibilities of research in this area and requires the development of new tools. Earlier we propose a method for studying the collective dynamics of the processes of autonomic control of blood circulation in the awake state and in different stages of sleep. The method is based on estimating a quantitative measure representing the total percentage of phase synchronization between the low-frequency oscillations in heart rate and blood pressure. Analysis of electrocardiogram and invasive blood pressure signals in apnea patients in the awake state and in different sleep stages showed a high sensitivity of the proposed measure. It is shown that in slow-wave sleep the degree of synchronization of the studied rhythms is higher than in the awake state and lower than in sleep with rapid eye movement. The results reflect the modulation of the processes of autonomic control of blood circulation by higher nervous activity and can be used for the quantitative assessment of this modulation.

AB - The influence of higher nervous activity on the processes of autonomic control of the cardiovascular system and baroreflex regulation is of considerable interest, both for understanding the fundamental laws of the functioning of the human body and for developing methods for diagnostics and treatment of pathologies. The complexity of the analyzed systems limits the possibilities of research in this area and requires the development of new tools. Earlier we propose a method for studying the collective dynamics of the processes of autonomic control of blood circulation in the awake state and in different stages of sleep. The method is based on estimating a quantitative measure representing the total percentage of phase synchronization between the low-frequency oscillations in heart rate and blood pressure. Analysis of electrocardiogram and invasive blood pressure signals in apnea patients in the awake state and in different sleep stages showed a high sensitivity of the proposed measure. It is shown that in slow-wave sleep the degree of synchronization of the studied rhythms is higher than in the awake state and lower than in sleep with rapid eye movement. The results reflect the modulation of the processes of autonomic control of blood circulation by higher nervous activity and can be used for the quantitative assessment of this modulation.

KW - apnea

KW - autonomic control

KW - blood pressure

KW - cardiovascular system

KW - interbeat intervals

KW - sleep studies

KW - synchronization

UR - http://www.scopus.com/inward/record.url?scp=85123402154&partnerID=8YFLogxK

U2 - 10.3389/fnins.2021.791510

DO - 10.3389/fnins.2021.791510

M3 - Article

AN - SCOPUS:85123402154

VL - 15

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-453X

M1 - 791510

ER -