TY - JOUR

T1 - Sustained neurotransmitter release

T2 - New molecular clues

AU - Brodin, L.

AU - Low, P.

AU - Gad, H.

AU - Gustafsson, J.

AU - Pieribone, V. A.

AU - Shupliakov, O.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Chemical synapses convey impulses at high frequency by exocytosis of synaptic vesicles. To avoid failure of synaptic transmission, rapid replenishment of synaptic vesicles must occur. Recent molecular perturbation studies have confirmed that the recycling of synaptic vesicles involves clathrin-mediated endocytosis. The rate of exocytosis would thus be limited by the capacity of the synaptic clathrin machinery unless vesicles could be drawn from existing pools. The mobilization of vesicles from the pool clustered at the release sites appears to provide a mechanism by which the rate of exocytosis can intermittently exceed the rate of recycling. Perturbation of synapsins causes disruption of vesicle clusters and impairment of synaptic transmission at high but not at low frequencies. Both clathrin-mediated recycling and mobilization of vesicles from the reserve pool are thus important in the replenishment of synaptic vesicles. The efficacy of each mechanism appears to differ between synapses which operate with different patterns of activity.

AB - Chemical synapses convey impulses at high frequency by exocytosis of synaptic vesicles. To avoid failure of synaptic transmission, rapid replenishment of synaptic vesicles must occur. Recent molecular perturbation studies have confirmed that the recycling of synaptic vesicles involves clathrin-mediated endocytosis. The rate of exocytosis would thus be limited by the capacity of the synaptic clathrin machinery unless vesicles could be drawn from existing pools. The mobilization of vesicles from the pool clustered at the release sites appears to provide a mechanism by which the rate of exocytosis can intermittently exceed the rate of recycling. Perturbation of synapsins causes disruption of vesicle clusters and impairment of synaptic transmission at high but not at low frequencies. Both clathrin-mediated recycling and mobilization of vesicles from the reserve pool are thus important in the replenishment of synaptic vesicles. The efficacy of each mechanism appears to differ between synapses which operate with different patterns of activity.

KW - Dynamin

KW - Endocytosis

KW - Exocytosis

KW - Synapsin

KW - Synaptic vesicle

UR - http://www.scopus.com/inward/record.url?scp=0031418918&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.1997.tb01679.x

DO - 10.1111/j.1460-9568.1997.tb01679.x

M3 - Review article

C2 - 9517455

AN - SCOPUS:0031418918

VL - 9

SP - 2503

EP - 2511

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 12

ER -