TY - JOUR

T1 - Surface-enhanced Raman scattering of sulfo-cyanine NHS esters adsorbed on gold nanoparticles

AU - Шевчук, Алиса Игоревна

AU - Смирнов, Алексей Николаевич

AU - Свинко, Василиса Олеговна

AU - Соловьева, Елена Викторовна

N1 - 6. A. I. Shevchuk, A. N. Smirnov, V. O. Svinko E. V. Solovyeva Surface-enhanced Raman scattering of sulfo-cyanine NHS esters adsorbed on gold nanoparticles. Russian Journal of General Chemistry, 2024 S20-S27

PY - 2024

Y1 - 2024

N2 - Abstract: Cyanine dyes are widely used in various techniques of bioimaging. The development of new types of optical tags with cyanine dyes combined with plasmonic nanoparticles is of great interest. In this work, surface-enhanced Raman scattering (SERS) study of optical behavior of cyanines adsorbed on gold nanoparticles in suspensions is presented to predict the optical response of corresponding tags. Two dyes, sulfo-cyanine 5.5 NHS ester and sulfo-cyanine 7.5 NHS ester were considered as they are suitable for the first transparency window of biological tissues. Gold nanoparticles of anisotropic shape were used as a plasmonic substrate. The assignment of bands in SERS spectra of both dyes was performed based on DFT calculations of vibrational frequencies of the molecules. The adsorption of dyes on the nanoparticles with different surface charges was studied. Spectral changes showed that a reorientation of the molecules occurs and reactive NHS ester tail is more accessible sterically in the case of a positive surface charge. The effect of aggregation-induced agent on the SERS response of sulfo-cyanines was also studied. Addition of chloride anions led to about five-fold increase of SERS intensity for sulfo-cyanine 5.5 NHS ester.

AB - Abstract: Cyanine dyes are widely used in various techniques of bioimaging. The development of new types of optical tags with cyanine dyes combined with plasmonic nanoparticles is of great interest. In this work, surface-enhanced Raman scattering (SERS) study of optical behavior of cyanines adsorbed on gold nanoparticles in suspensions is presented to predict the optical response of corresponding tags. Two dyes, sulfo-cyanine 5.5 NHS ester and sulfo-cyanine 7.5 NHS ester were considered as they are suitable for the first transparency window of biological tissues. Gold nanoparticles of anisotropic shape were used as a plasmonic substrate. The assignment of bands in SERS spectra of both dyes was performed based on DFT calculations of vibrational frequencies of the molecules. The adsorption of dyes on the nanoparticles with different surface charges was studied. Spectral changes showed that a reorientation of the molecules occurs and reactive NHS ester tail is more accessible sterically in the case of a positive surface charge. The effect of aggregation-induced agent on the SERS response of sulfo-cyanines was also studied. Addition of chloride anions led to about five-fold increase of SERS intensity for sulfo-cyanine 5.5 NHS ester.

KW - adsorption

KW - cyanines

KW - dyes

KW - gold nanoparticles

KW - surface-enhanced Raman scattering

UR - https://www.mendeley.com/catalogue/fb08998d-f818-3d5a-8502-25edf2b90973/

U2 - 10.1134/S1070363224140032

DO - 10.1134/S1070363224140032

M3 - статья

VL - 94

SP - S20-S27

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - Suppl 1

ER -