TY - JOUR

T1 - Studying CNS effects of Traditional Chinese Medicine using zebrafish models

AU - Wang, Dongmei

AU - Hu, Guojun

AU - Wang, Jingtao

AU - Yan, Dongni

AU - Wang, Mengyao

AU - Yang, LongEn

AU - Serikuly, Nazar

AU - Alpyshov, Erik

AU - Demin, Konstantin A

AU - Galstyan, David S

AU - Amstislavskaya, Tamara G

AU - de Abreu, Murilo S

AU - Kalueff, Allan V

N1 - Publisher Copyright: © 2020 Elsevier B.V.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Ethnopharmacological relevance: Although Traditional Chinese Medicine (TCM) has a millennia-long history of treating human brain disorders, its complex multi-target mechanisms of action remain poorly understood. Animal models are currently widely used to probe the effects of various TCMs on brain and behavior. The zebrafish (Danio rerio) has recently emerged as a novel vertebrate model organism for neuroscience research, and is increasingly applied for CNS drug screening and development. Aim of the study: As zebrafish models are only beginning to be applied to studying TCM, we aim to provide a comprehensive review of the TCM effects on brain and behavior in this fish model species. Materials and methods: A comprehensive search of published literature was conducted using biomedical databases (Web of Science, Pubmed, Sciencedirect, Google Scholar and China National Knowledge Internet, CNKI), with key search words zebrafish, brain, Traditional Chinese Medicine, herbs, CNS, behavior. Results: We recognize the developing utility of zebrafish for studying TCM, as well as outline the existing model limitations, problems and challenges, as well as future directions of research in this field. Conclusions: We demonstrate the growing value of zebrafish models for studying TCM, aiming to improve our understanding of TCM’ therapeutic mechanisms and potential in treating brain disorders.

AB - Ethnopharmacological relevance: Although Traditional Chinese Medicine (TCM) has a millennia-long history of treating human brain disorders, its complex multi-target mechanisms of action remain poorly understood. Animal models are currently widely used to probe the effects of various TCMs on brain and behavior. The zebrafish (Danio rerio) has recently emerged as a novel vertebrate model organism for neuroscience research, and is increasingly applied for CNS drug screening and development. Aim of the study: As zebrafish models are only beginning to be applied to studying TCM, we aim to provide a comprehensive review of the TCM effects on brain and behavior in this fish model species. Materials and methods: A comprehensive search of published literature was conducted using biomedical databases (Web of Science, Pubmed, Sciencedirect, Google Scholar and China National Knowledge Internet, CNKI), with key search words zebrafish, brain, Traditional Chinese Medicine, herbs, CNS, behavior. Results: We recognize the developing utility of zebrafish for studying TCM, as well as outline the existing model limitations, problems and challenges, as well as future directions of research in this field. Conclusions: We demonstrate the growing value of zebrafish models for studying TCM, aiming to improve our understanding of TCM’ therapeutic mechanisms and potential in treating brain disorders.

KW - Brain

KW - CNS effects

KW - Drug screening

KW - Traditional Chinese medicine

KW - Zebrafish

KW - OXIDATIVE STRESS

KW - ALZHEIMERS-DISEASE

KW - HERBAL MEDICINE

KW - VIVO DRUG DISCOVERY

KW - ADULT ZEBRAFISH

KW - IN-VITRO

KW - PANAX-NOTOGINSENG

KW - MONOCLONAL-ANTIBODIES

KW - CEREBRAL-ISCHEMIA

KW - COGNITIVE DEFICITS

UR - http://www.scopus.com/inward/record.url?scp=85096375626&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/cacd0979-a512-3a33-b342-38396c9fbf22/

U2 - 10.1016/j.jep.2020.113383

DO - 10.1016/j.jep.2020.113383

M3 - Review article

C2 - 32918992

VL - 267

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - March

M1 - 113383

ER -